The predictive specificity of psychological vulnerability markers for the course of affective disorders

Journal of Psychiatric Research
Sascha Y StruijsBrenda W J H Penninx

Abstract

High scores on markers of psychological vulnerability have been associated with a worse course of affective disorders. However, little is known about the specificity of those associations in predicting the course of different depressive and anxiety disorders. We examined the impact of psychological vulnerability on the short- and long-term course of depressive and anxiety disorders. Participants from the Netherlands Study of Depression and Anxiety with a current diagnosis of depression or anxiety (n = 1256) were reassessed after 2 and 6 years. Diagnostic status and chronic duration (>85% of the time) of symptoms were the outcomes. Predictors were neuroticism, extraversion, locus of control, cognitive reactivity (rumination and hopelessness reactivity), worry and anxiety sensitivity. High neuroticism, low extraversion and external locus of control predicted chronicity of various affective disorders. Rumination, however, predicted chronicity of depressive but not anxiety disorders. Worry specifically predicted chronicity of GAD and anxiety sensitivity predicted chronicity of panic disorder and social anxiety disorder. These patterns were present both at short-term and at long-term, without losing predictive accuracy. Psychologica...Continue Reading

Citations

Aug 27, 2019·Brain and Behavior·Ángel Rodríguez-RamosManuel Ruiz-Rubio
Jun 24, 2020·Journal of Clinical Medicine·Marion VouteGisèle Pickering
Feb 14, 2021·The Lancet. Psychiatry·Johanna H M Hovenkamp-HermelinkRobert A Schoevers
Aug 31, 2021·Nordic Journal of Psychiatry·Stine Bjerrum MoellerPoul Videbech

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