PMID: 8947817Oct 1, 1996Paper

The predictive value of an initial serum beta human chorionic gonadotropin level for pregnancy outcome following in vitro fertilization

Journal of Assisted Reproduction and Genetics
S M QasimJ K Choe

Abstract

Our purpose was to assess the predictive value for pregnancy outcome of an initial serum quantitative beta-hCG measurement obtained 11 or 12 days after embryo transfer in an in vitro fertilization program. A prospective, descriptive study of 153 pregnancies achieved via in vitro fertilization-embryo transfer was performed. Initial beta-hCG levels and subsequent pregnancy outcomes were compared. The overall mean initial beta-hCG level was 91 +/- 85.8 mIU/ml for normal (singleton, multiple-gestation) pregnancies and 29 +/- 24.9 mIU/ml for abnormal (miscarriage, ectopic) pregnancies (P < 0.01; power, > 80%). While 93.9% of patients with initial beta-hCG levels > or = 42 mIU/ml had normal pregnancies, 56.4% of those with initial levels < 42 mIU/ml experienced abnormal outcomes. With 42 mIU/ml as the cutoff level for predicting a normal pregnancy, this screening test yielded a sensitivity of 79.3% and a specificity of 83.8%. Initial serum beta-hCG levels obtained 11 or 12 days after embryo transfer may be predictive of pregnancy outcome in an in vitro fertilization program.

References

Oct 1, 1991·Journal of in Vitro Fertilization and Embryo Transfer : IVF·T LevyD Feldberg
Jun 1, 1990·Fertility and Sterility·J B DubuissonL Mandelbrot
Aug 1, 1988·Journal of in Vitro Fertilization and Embryo Transfer : IVF·D KreinerZ Rosenwaks

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Citations

Jul 3, 2002·Human Reproduction·P PoikkeusAila Tiitinen
Nov 20, 2012·Journal of Human Reproductive Sciences·Madhuri Patil
Jul 4, 2009·Reproductive Biomedicine Online·Travis W McCoyHenry Cl Bohler
Oct 12, 2000·Baillière's Best Practice & Research. Clinical Obstetrics & Gynaecology·S Sunder, E A Lenton
Mar 28, 2017·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Mona DahiyaHemashree Rajesh
Feb 10, 2006·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Marieke J LambersPeter G A Hompes
Dec 31, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nienke E van TrommelChris M Thomas
Apr 24, 2020·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Yixuan Wu, Haiying Liu
Mar 13, 2014·Journal of Hypertension·John Webster
Sep 25, 2004·Human Reproduction Update·Herve Fernandez, Amelie Gervaise
Mar 4, 2021·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·C J Valdera SimbrónM Albi González

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