The predictive value of C-reactive protein and erythrocyte sedimentation rate for 18F-FDG PET/CT outcome in patients with fever and inflammation of unknown origin

Nuclear Medicine Communications
Hans BalinkHein J Verberne

Abstract

The objective of this study was to determine the predictive value of C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) to a positive fluorine-18 fluorodeoxyglucose ((18)F-FDG) PET/computed tomography (CT) result in patients with inflammation of unknown origin and fever of unknown origin. Individual data of 498 patients were retrieved from three retrospective studies. Receiver operating characteristic derived areas under the curve were used to assess (18)F-FDG PET/CT versus age, CRP, and ESR. The discriminative value of age, CRP, and ESR related to (18)F-FDG PET/CT was examined using the net reclassification improvement (NRI). A diagnosis was established in 331 patients; (18)F-FDG PET/CT had a diagnostic accuracy of 89%. (18)F-FDG PET/CT had the highest area under the curve (0.89, P<0.001). The addition of (18)F-FDG PET/CT to a diagnosis prediction model including age, CRP, and ESR resulted in an NRI of 42% (P<0.001). In the same model with CRP values below 20 mg/l or ESR values below 20 mm/h, the NRI was 64% (P<0.001) and 29% (P=0.059), respectively. In 30 of 91 patients with CRP less than 10 mg/l, a diagnosis could be established; (18)F-FDG PET/CT was 100% true negative only in patients with CRP levels less tha...Continue Reading

References

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Mar 26, 2014·Clinical Nuclear Medicine·Hans BalinkHein J Verberne

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Citations

Sep 13, 2016·Nuklearmedizin. Nuclear Medicine·Caroline BouterJohannes Meller
Jul 9, 2020·Journal of Clinical Medicine·Stamata GeorgaGeorgios Arsos
Jan 27, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Wen-Xia WangJian-Xin Song
Jul 5, 2019·The Quarterly Journal of Nuclear Medicine and Molecular Imaging : Official Publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of Radiopharmaceutica·Catharina M Mulders-MandersChantal P Bleeker-Rovers
Mar 21, 2020·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Reyhan Bilici SalmanMehmet Akif Öztürk

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Methods Mentioned

BETA
ESR
biopsy

Software Mentioned

SAS

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