The predictive value of different measures of obesity for incident cardiovascular events and mortality

The Journal of Clinical Endocrinology and Metabolism
Harald J SchneiderHans-Ulrich Wittchen

Abstract

To date, it is unclear which measure of obesity is the most appropriate for risk stratification. The aim of the study was to compare the associations of various measures of obesity with incident cardiovascular events and mortality. We analyzed two German cohort studies, the DETECT study and SHIP, including primary care and general population. A total of 6355 (mean follow-up, 3.3 yr) and 4297 (mean follow-up, 8.5 yr) individuals participated in DETECT and SHIP, respectively. We measured body mass index (BMI), waist circumference (WC), waist-to-height ratio (WHtR), and waist-to-hip ratio (WHR) and assessed cardiovascular and all-cause mortality and the composite endpoint of incident stroke, myocardial infarction, or cardiovascular death. In both studies, we found a positive association of the composite endpoint with WHtR but not with BMI. There was no heterogeneity among studies. The relative risks in the highest versus the lowest sex- and age-specific quartile of WHtR, WC, WHR, and BMI after adjustment for multiple confounders were as follows in the pooled data: cardiovascular mortality, 2.75 (95% confidence interval, 1.31-5.77), 1.74 (0.84-3.6), 1.71 (0.91-3.22), and 0.74 (0.35-1.57), respectively; all-cause mortality, 1.86 (1....Continue Reading

References

Mar 29, 1990·The New England Journal of Medicine·J E MansonC H Hennekens
Feb 10, 1996·BMJ : British Medical Journal·M AshwellK McPherson
Dec 7, 1996·BMJ : British Medical Journal·B D Cox, M Whichelow
May 23, 2001·JAMA : the Journal of the American Medical Association·UNKNOWN Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
Apr 22, 2003·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·S D HsiehT Muto
Aug 23, 2003·Journal of the American College of Cardiology·Barnaby C ReevesGianni D Angelini
Nov 6, 2003·Annals of Epidemiology·Sai-Yin HoUNKNOWN Hong Kong Cardiovascular Risk Factor Prevalence Study Steering Committee
Mar 11, 2004·JAMA : the Journal of the American Medical Association·Ali H MokdadJulie L Gerberding
Mar 23, 2004·American Journal of Epidemiology·Guangyong Zou
Apr 21, 2005·JAMA : the Journal of the American Medical Association·Katherine M FlegalMitchell H Gail
May 19, 2005·Current Medical Research and Opinion·H-U WittchenUNKNOWN DETECT-Study Group
Apr 4, 2006·Lancet·Harald Jörn SchneiderHans-Ulrich Wittchen
Aug 24, 2006·The New England Journal of Medicine·Kenneth F AdamsMichael F Leitzmann
Aug 24, 2006·The New England Journal of Medicine·Sun Ha JeeJonathan M Samet
Oct 18, 2006·Journal of Korean Medical Science·Chang Won WonMichi Yukawa
Nov 16, 2006·The Journal of Clinical Endocrinology and Metabolism·Harald J SchneiderUNKNOWN DETECT Study Group
Nov 8, 2007·JAMA : the Journal of the American Medical Association·Katherine M FlegalMitchell H Gail
Mar 22, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Jean-Pierre DesprésPaul Poirier
Mar 25, 2008·Journal of Clinical Epidemiology·Crystal Man Ying LeeMark Woodward
Aug 16, 2008·Journal of the American College of Cardiology·Rebecca P GelberTobias Kurth
Sep 25, 2008·Epidemiology·Aimin ChenWalter J Rogan
Oct 30, 2008·BMC Medical Research Methodology·Johanna C DekkersWillem van Mechelen
Nov 14, 2008·The New England Journal of Medicine·T PischonE Riboli

❮ Previous
Next ❯

Citations

Apr 23, 2011·Der Radiologe·M Slawik, F Beuschlein
Oct 12, 2011·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·Dorothea KesztyüsJürgen M Steinacker
May 12, 2012·The British Journal of Nutrition·Noora KanervaSatu Männistö
Jun 16, 2011·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S C BischoffT Ellrott
May 18, 2013·European Journal of Sport Science·Markus KleinEike Emrich
Jan 8, 2013·Metabolic Syndrome and Related Disorders·Valter SilvaAntonio José Grande
Apr 12, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Frank-Peter TillmannGerd R Hetzel
Feb 3, 2011·BMC Cardiovascular Disorders·N NordstrandJ Hjelmesæth
Sep 14, 2013·BMC Psychiatry·Jörg WiltinkManfred E Beutel
Jun 7, 2013·BMC Public Health·Francisco Javier Félix-RedondoDaniel Fernández-Bergés
Aug 21, 2013·BMC Endocrine Disorders·Wen-Yu LinYung-Po Liaw
Mar 8, 2012·Cardiovascular Diabetology·Bozorgmanesh MohammadrezaAzizi Fereidoun Fereidoun Prof
Oct 28, 2011·The Journal of Clinical Endocrinology and Metabolism·Arthur HartzAlfred Rimm
Dec 8, 2011·Journal of Pediatric Endocrinology & Metabolism : JPEM·Gal Dubnov-RazNaama W Constantini
Sep 4, 2013·International Journal of Environmental Research and Public Health·Samantha L LoganLawrence L Spriet
Sep 8, 2011·Indian Journal of Endocrinology and Metabolism·Rakesh M Parikh
Jul 6, 2014·PloS One·Benjamin W DomingueJason D Boardman
May 25, 2013·Sleep & Breathing = Schlaf & Atmung·Wish BanhiranCheerasook Chongkolwatana
Oct 10, 2013·Public Health Nutrition·Reci MeseriBelgin Unal
Jul 1, 2014·European Journal of Endocrinology·Andrea OßwaldMartin Reincke
Oct 14, 2014·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Hamiyet Donmez-AltuntasHalit Diri
Aug 31, 2014·Annals of the American Thoracic Society·Michael G S Shashaty, Renee D Stapleton
Aug 1, 2014·PloS One·Anna Karla Carneiro RorizLílian Ramos Sampaio
Mar 23, 2011·Der Internist·K A IwenJ Klein
Jan 19, 2015·European Journal of Nutrition·Mohammadreza BozorgmaneshFarzad Hadaegh
Jan 24, 2016·Journal of Translational Medicine·Javier Martinez-Useros, Jesus Garcia-Foncillas
Mar 16, 2013·The Surgeon : Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·Tabita M ValentijnRobert Jan Stolker
Nov 22, 2012·Journal of the American Medical Directors Association·Ellen L de HollanderLisette C P G M de Groot

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

© 2021 Meta ULC. All rights reserved