The predictive value of early life total immunoglobulin E measurement in identifying atopic children in a population-based birth cohort study.

Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology
Michael R PerkinALSPAC Study Team

Abstract

Atopy is common and the prevalence amongst children is rising. Measurements in early childhood that can predict subsequent development of atopy could be clinically useful for targeting preventive measures. We used the Children in Focus (CiF) subgroup of a large population-based birth cohort study (the Avon Longitudinal Study of Parents and Children) to investigate whether total immunoglobulin E (IgE) measured at 12 and 18 months could predict subsequent development of atopy at 5 yr of age. Atopy was determined by positive skin prick test (> or = 3 mm wheal) to one or more of 14 inhalant and food allergens. Prevalence of skin prick positivity to any allergen was 14.5% (104 of 715; 95% CI: 12.0-17.1%). Total IgE levels were significantly higher at 12 months of age (p < 0.0005) but not 18 months of age in those children subsequently atopic. The highest positive predictive value was 41% with an IgE measurement of >51 kU/l, with a sensitivity of 13.5% and a specificity of 95.8%. Although significant differences in early life IgE measurements were seen, the extent of overlap was great, such that the overall performance of IgE at 12 months as a screening test for atopy was poor.

References

Aug 1, 1992·Archives of Disease in Childhood·S DoldE Stiepel
Feb 1, 1990·Acta paediatrica Scandinavica·N Aberg, I Engström
Nov 18, 1989·BMJ : British Medical Journal·D P Strachan
May 1, 1982·Archives of Disease in Childhood·S CronerA Roth
Jan 19, 1995·The New England Journal of Medicine·F D MartinezW J Morgan
Jul 16, 1994·BMJ : British Medical Journal·D G Altman, J M Bland
Apr 30, 1994·BMJ : British Medical Journal·H C WilliamsR J Hay
Jul 1, 1997·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R L BergmannU Wahn
May 26, 1998·The Journal of Allergy and Clinical Immunology·S M TariqD W Hide
Nov 21, 1998·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·N KondoY Yokoyama
Feb 27, 1999·European Journal of Pediatrics·L F De Swert
Aug 17, 1999·Archives of Disease in Childhood. Fetal and Neonatal Edition·S E Mumford
Aug 24, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S M TariqE A Hakim
Oct 19, 1999·Archives of Disease in Childhood. Fetal and Neonatal Edition·S E Mumford
Dec 11, 1999·BMJ : British Medical Journal·N J WaldC D Frost
Dec 8, 2000·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·K OymarR Bjerknes
Mar 10, 2001·Paediatric and Perinatal Epidemiology·J GoldingUNKNOWN ALSPAC Study Team
Apr 12, 2001·The British Journal of Dermatology·J M HarrisA J Newman Taylor
Jul 27, 2001·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·V H van der VeldenH F Savelkoul
Sep 12, 2001·Allergy·S G JohanssonUNKNOWN EAACI (the European Academy of Allergology and Cinical Immunology) nomenclature task force
Oct 3, 2001·Pediatrics·M D KlinnertD A Mrazek
Jun 6, 2003·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Ramesh KurukulaaratchyS Hasan Arshad
May 15, 2004·American Journal of Respiratory and Critical Care Medicine·Ashley WoodcockUNKNOWN NAC Manchester Asthma and Allergy Study Group
Jun 24, 2004·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Michael R PerkinUNKNOWN ALSPAC Study Team
Jul 9, 2004·The Journal of Allergy and Clinical Immunology·Carsten FlohrHywel Williams

❮ Previous
Next ❯

Citations

Apr 10, 2013·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Yenny DjuardiMaria Yazdanbakhsh
Aug 1, 2012·The Journal of Allergy and Clinical Immunology·Marie HerrIsabelle Momas
Mar 1, 2011·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Purvee S ShahEdward M Zoratti
Dec 4, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P M MatricardiS Lau
Jun 6, 2009·Paediatric and Perinatal Epidemiology·Jean Golding
Jan 29, 2008·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·M E LevinC Motala
Nov 23, 2011·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Giovanni MelioliGiovanni Passalacqua
Apr 29, 2009·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Mikko LappalainenMaija-Riitta Hirvonen
Nov 26, 2010·The Journal of Allergy and Clinical Immunology·Yize I WanIan Sayers

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.