The Predictive Value of Indocyanine Green Clearance in Future Liver Remnant for Posthepatectomy Liver Failure Following Hepatectomy with Extrahepatic Bile Duct Resection

World Journal of Surgery
Yukihiro YokoyamaMasato Nagino

Abstract

Postoperative liver failure (PHLF) is one of the most common complications following major hepatectomy. The preoperative assessment of future liver remnant (FLR) function is critical to predict the incidence of PHLF. To determine the efficacy of the plasma clearance rate of indocyanine green clearance of FLR (ICGK-F) in predicting PHLF in cases of highly invasive hepatectomy with extrahepatic bile duct resection. Five hundred and eighty-five patients who underwent major hepatectomy with extrahepatic bile duct resection, from 2002 to 2014 in a single institution, were evaluated. Among them, 192 patients (33 %) had PHLF. The predictive value of ICGK-F for PHLF was determined and compared with other risk factors for PHLF. The incidence of PHLF was inversely proportional to the level of ICGK-F. With multivariate logistic regression analysis, ICGK-F, combined pancreatoduodenectomy, the operation time, and blood loss were identified as independent risk factors of PHLF. The risk of PHLF increased according to the decrement of ICGK-F (the odds ratio of ICGK-F for each decrement of 0.01 was 1.22; 95 % confidence interval 1.12-1.33; P < 0.001). Low ICGK-F was also identified as an independent risk factor predicting the postoperative mort...Continue Reading

References

Mar 30, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H ImamuraS Kawasaki
Mar 26, 2004·Surgery·Eddie K AbdallaJean-Nicolas Vauthey
Mar 9, 2005·Journal of Hepato-biliary-pancreatic Surgery·Sung-Gyu Lee, Shin Hwang
Mar 19, 2008·Archives of Surgery·Yukihiro YokoyamaYuji Nimura
Oct 7, 2009·Journal of Hepato-biliary-pancreatic Sciences·Tsuyoshi IgamiMasato Nagino
Mar 24, 2012·Digestive Surgery·Alfredo GuglielmiCalogero Iacono
Nov 28, 2013·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·Y KasaiS Uemoto
Jan 9, 2014·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Yasuo OhkuraShuji Isaji
May 8, 2015·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Shin HwangSung-Gyu Lee

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Citations

Feb 28, 2020·Annals of Surgical Oncology·Pim B OlthofUNKNOWN Perihilar Cholangiocarcinoma Collaboration Group
Sep 8, 2020·Surgery Today·Yoji Kishi, Jean-Nicolas Vauthey
Dec 4, 2019·Annals of Gastroenterological Surgery·Masato Nagino
Jul 14, 2016·World Journal of Surgery·Pim B OlthofThomas M van Gulik
Sep 15, 2018·Annals of Hepato-biliary-pancreatic Surgery·Ken Min ChinSer Yee Lee
Nov 8, 2017·Metabolomics : Official Journal of the Metabolomic Society·Masahito UjiMasato Nagino
Jan 15, 2018·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·Ikuo NakamuraJiro Fujimoto
Dec 2, 2020·Journal of Hepato-biliary-pancreatic Sciences·Masato NaginoItaru Endo
Apr 5, 2019·Annals of Surgery·Kentaro ShinoharaMasato Nagino
Nov 5, 2019·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Yutaka NakanoYuko Kitagawa
Feb 20, 2021·Annals of Surgery·Hauke Lang, Thomas M van Gulik
Jun 7, 2021·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Kenji YoshinoJavier Briceño-Delgado
Feb 15, 2020·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Federico TomassiniRoberto I Troisi
Sep 26, 2020·Annals of Surgery·Takashi MizunoMasato Nagino

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