The predictive value of soluble endothelial selectin plasma levels in children with acute lung injury

Journal of Critical Care
Mohammed A Al-BiltagiHossam Ahmed Mourad

Abstract

The study aimed to evaluate the value of soluble endothelial selectin (sE-selectin) plasma level measurement in predicting acute lung injury (ALI) outcome in children. The study was a prospective, controlled study that involved 50 children with ALI and 50 healthy children as a control. Soluble endothelial selectin and C-reactive protein plasma levels were measured at days 1 and 7 of development of ALI for the patient group and done only once for the control group. Plasma sE-selectin was significantly higher in the patients than the control group (P = .001). Mortality reached 32% of children with ALI. The deceased subgroup had significantly higher plasma sE-selectin levels both at days 1 and 7 than the survived (P = .02 and P < .001 respectively). There was positive correlation between plasma sE-selectin at day 7 with durations of both pediatric intensive care unit and mechanical ventilation. Levels of sE-selectin at days 1 and 7 had significant positive correlation with C-reactive protein level and ALI severity. Soluble endothelial selectin plasma levels of 302 ng/mL at day 7 were the best cutoff value to predict ALI-related deaths. Plasma sE-selectin level served as a good predictor biomarker for both mechanical ventilation du...Continue Reading

References

Nov 11, 1992·JAMA : the Journal of the American Medical Association·C C Berry
Mar 1, 1994·American Journal of Respiratory and Critical Care Medicine·G R BernardR Spragg
Mar 28, 1998·American Journal of Respiratory and Critical Care Medicine·S KayalJ Labrousse
Mar 9, 1999·International Immunology·B NeumannB Holzmann
May 11, 2002·Critical Care Medicine·Konrad ReinhartMichael Meisner
Dec 13, 2006·Translational Research : the Journal of Laboratory and Clinical Medicine·Kenji OkajimaTakao Nakagawa
Feb 14, 2007·Chest·Gordon D Rubenfeld, Margaret S Herridge
Jul 1, 2009·Pediatrics·Jerry J ZimmermanGordon D Rubenfeld
May 26, 2011·International Journal of Medical Sciences·Daisuke OsakaIsao Kubota
Dec 21, 2012·Journal of Korean Medical Science·Young Joo HanYoung Yull Koh

❮ Previous
Next ❯

Citations

Jun 18, 2016·Frontiers in Pediatrics·Benjamin E Orwoll, Anil Sapru
Nov 26, 2020·International Journal of Molecular Sciences·Alice G VassiliouStylianos E Orfanos
Oct 3, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Yu-Qiong HeWan-Sheng Chen
Jan 10, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zihe DingZunpeng Shu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.

Related Papers

Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Heidi FloriMichael A Matthay
Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Simon EricksonAustralian and New Zealand Intensive Care Society
Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine
Georgene SinghNagamani Sen
© 2022 Meta ULC. All rights reserved