The predictive value of the 1-h 50-g glucose screen for diagnosing gestational diabetes mellitus in a high-risk population

The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Susan Lanni, Diane Barrett

Abstract

To determine a value, for a gestational diabetes mellitus (GDM) screening test, above which the glucose tolerance test is obviated. A database search of patients delivered at the Medical College of Virginia Hospital (MCV) between April 1991 and April 2002 was undertaken. Subjects were screened using standard methodology: blood glucose level 1 h after a 50-g oral glucose load (1OGT). Subjects with values meeting/exceeding 140 mg/dl underwent 3-h 100-g oral glucose tolerance tests (3OGTT). GDM was diagnosed using criteria of the National Diabetes Data Group (NDDG), with Carpenter-Coustan (CC) criteria for comparison. Receiver-operator characteristic (ROC) curves were generated; areas under the curve (AUC) were calculated. 1OGT results were available for 16898 subjects; 2770 (16.4%) had values meeting/exceeding 140 mg/dl. The NDDG and CC criteria were applied to 1972 subjects with both 1OGT and 3OGTT results available: 419 (21%) and 614 (31%) subjects had GDM, respectively. Positive predictive values for results > or =180 mg/dl and values at 20 mg/dl increments up to 260 mg/dl were: 36, 47, 55, 57 and 63% (NDDG) and 45, 54, 62, 61 and 66% (CC). AUC for NDDG=0.68; AUC for CC=0.64. GDM cannot be diagnosed with the 1OGT; predictive v...Continue Reading

References

Dec 1, 1982·American Journal of Obstetrics and Gynecology·M W Carpenter, D R Coustan
Nov 1, 1996·The Journal of Maternal-fetal Medicine·R A BobrowskiM P Dombrowski
Nov 16, 1999·American Journal of Obstetrics and Gynecology·L C AtilanoR L Barbieri

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Citations

May 30, 2009·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Aydan BiriOzdemir Himmetoglu
Nov 28, 2006·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Yvonne W ChengAaron B Caughey
Jan 23, 2016·Journal of Perinatology : Official Journal of the California Perinatal Association·L A TemmingA G Cahill
May 16, 2014·Canadian Journal of Diabetes·David ThompsonChristina Vinokuroff
Jan 7, 2009·Diabetes Research and Clinical Practice·Vincent W WongBin Jalaludin
Dec 11, 2007·Diabetes Research and Clinical Practice·Umit KorucuogluYildiz Atalay
Sep 6, 2013·Clinical Obstetrics and Gynecology·Edmond A Ryan

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