The predominance of metabolic regulation of cerebral blood flow and the lack of "Classic" autoregulation curves in the viable brain.

Surgical Neurology International
George I Chovanes, Rafael M Richards

Abstract

The influence of cerebral perfusion pressure (CPP) on real-time focal cerebral blood flow (fCBF) is not fully understood, in either intact or injured brain. We wanted to evaluate that relationship, and by implication investigate the relative importance of perfusion pressure versus metabolism in the regulation and control of cerebral blood flow. Our hypothesis was that metabolic needs dominated over a physiologic range of blood pressure. This was an observational study of 23 patients, most of them with closed head injury, three with subarachnoid hemorrhage, one with a gunshot wound to the brain, and one monitored after craniotomy for unruptured aneurysm. Arterial lines, ventriculostomies, and fCBF monitors were placed. CPP (mean arterial pressure - intracranial pressure) and fCBF were measured and recorded to a computer database every minute. The relationship between CPP and fCBF was graphed and correlation coefficients were compared between survivors and non-survivors. Graphs of CPP versus fCBF did not show any linearity over a range of 50-150 mm Hg in patients who survived. In those who died, four of seven showed some indication of linearity. The difference in the correlation coefficients between survivors and non-survivors wa...Continue Reading

References

Oct 1, 1991·Journal of Neurosurgery·D LombardiJ A Katzmann
Sep 1, 1990·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·U I TuorJ McCulloch
Jan 1, 1985·Annals of Biomedical Engineering·G L Baumbach, D D Heistad
Jan 1, 1985·Annals of Biomedical Engineering·H A Kontos, E P Wei
Jan 1, 1983·Stroke; a Journal of Cerebral Circulation·C GainesR M Crowell
Aug 9, 2002·Anesthesiology Clinics of North America·Monica S VavilalaArthur M Lam
Nov 26, 2002·Acta Physiologica Scandinavica·P KimmeF Sjöberg
Aug 30, 2003·Stroke; a Journal of Cerebral Circulation·Luzius A SteinerMarek Czosnyka
Apr 1, 1959·Physiological Reviews·N A LASSEN
Nov 6, 2003·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Luzius A SteinerJohn D Pickard
Dec 4, 2003·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Henrik FoltysRudolf Töpper
Apr 11, 2007·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·David C W LauUNKNOWN Obesity Canada Clinical Practice Guidelines Expert Panel
Oct 20, 2007·The Journal of Clinical Endocrinology and Metabolism·Marcos AbalovichAlex Stagnaro-Green

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Citations

Apr 26, 2012·Expert Opinion on Investigational Drugs·Christine BarryRobert Vink
May 24, 2014·The Journal of Trauma and Acute Care Surgery·Rao R Ivatury
May 19, 2020·Clinical and Experimental Hypertension : CHE·Noushin YazdaniSaeid Taheri
Aug 11, 2018·Frontiers in Physiology·Ali H EidHaissam Abou-Saleh

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