PMID: 2945165Jul 1, 1986

The preferential release of beta-endorphin from the anterior pituitary lobe by corticotropin releasing factor (CRF)

E A YoungHuda Akil


Although a number of investigators have shown that release of ACTH is accompanied by the release of Beta-endorphin (beta-End) and Beta-lipotropin (beta-LPH), the proportion of the latter two peptides released with stress or by CRF is unclear. To evaluate directly the release of beta-End versus beta-LPH from the anterior lobe, we used molecular sieving of plasma and subsequent radioimmunoassay to measure release of both beta-End and beta-LPH into plasma after thirty minutes of inescapable intermittent footshock. We found a substantial increase in circulating beta-End which appears to be of anterior lobe origin. The beta-End does not appear to represent peripheral conversion of beta-LPH to beta-End since the ratio of beta-LPH:beta-End released remained constant between five and thirty minutes of stress, and the rate of disappearance of beta-LPH is slower than the rate of disappearance of beta-End following the termination of stress. Further confirmation of these findings was obtained by examining the POMC derived peptides released by pituitary cell suspensions in the presence and absence of oCRF. While unstimulated release consisted of equal proportions of beta-End and beta-LPH, stimulation of the anterior lobe cell suspensions w...Continue Reading


Jun 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·A S LiottaD T Krieger
May 1, 1983·The Journal of Clinical Endocrinology and Metabolism·C A CahillHuda Akil


Aug 22, 1989·European Journal of Pharmacology·E A YoungHuda Akil
May 1, 1992·Pharmacology, Biochemistry, and Behavior·H M JohnstonD P Gilmore
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Related Concepts

Molecular Sieve Chromatography
Corticotropin-Releasing Hormone
Pituitary Gland, Anterior
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