PMID: 8592128Feb 1, 1996Paper

The prefrontal cortex regulates the basal release of dopamine in the limbic striatum: an effect mediated by ventral tegmental area

Journal of Neurochemistry
M Karreman, B Moghaddam

Abstract

The present study examined whether the prefrontal cortex (PFC) exerts a tonic control over the basal release of dopamine in the limbic striatum and whether this control is mediated by glutamatergic afferents to the dopamine cell body or terminal regions. Using intracerebral microdialysis in freely moving rats, it was demonstrated that application of tetrodotoxin in the contralateral PFC significantly decreased the release of dopamine in the medial striatum. Conversely, blockade of the tonic inhibitory GABAergic input in the PFC with bicuculline increased the release of dopamine in the medial striatum. Application of excitatory amino acid receptor antagonists into the striatum, while bicuculline was perfused in the PFC, did not affect the bicuculline-evoked dopamine increase in the striatum. However, infusion of tetrodotoxin or excitatory amino acid receptor antagonists into the ventral tegmental area, a region containing dopamine cell bodies that project to the medial striatum, blocked the stimulation of striatal dopamine release induced by infusion of bicuculline into the PFC. These data demonstrate that the basal output of dopamine terminals in the medial striatum is under a tonic excitatory control of the PFC. Furthermore, t...Continue Reading

Citations

Feb 26, 1999·Journal of Neurochemistry·F M Inglis, B Moghaddam
Feb 10, 2000·Journal of Psychopharmacology·M Laruelle, A Abi-Dargham
Sep 15, 2000·Journal of Neurochemistry·R Takahata, B Moghaddam
Mar 15, 2002·Neuroreport·Susan Jones, Johanna L Gutlerner
Sep 12, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Rossella VenturaStefano Puglisi-Allegra
Jun 17, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Peter FlagstadMichael Didriksen
Mar 15, 2005·Stress : the International Journal on the Biology of Stress·David W Self, Kwang-Ho Choi
Dec 6, 2005·The European Journal of Neuroscience·Antonio P StrafellaOury Monchi
Oct 12, 2010·Journal of Psychopharmacology·David J Houlihan
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Jun 27, 2014·Frontiers in Systems Neuroscience·Ilana Molochnikov, Dana Cohen
Jan 1, 1997·Journal of Psychopharmacology·L S Wilkinson
Jun 4, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Nathan S PentkowskiJanet L Neisewander
May 17, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Francisca Meyer, Alain Louilot
Aug 24, 2016·Cerebral Cortex·Stephanie McGarrityTobias Bast
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Jan 9, 2019·Journal of Neural Transmission·Stephanie A IhezieNachum Dafny
Dec 20, 2003·Annals of the New York Academy of Sciences·Anthony R WestAnthony A Grace

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