The pregnancy-induced increase in baseline circulating growth hormone in rats is not induced by ghrelin

Journal of Neuroendocrinology
Muna M El-KastiTimothy Wells

Abstract

The elevation in baseline circulating growth hormone (GH) that occurs in pregnant rats is thought to arise from increased pituitary GH secretion, but the underlying mechanism remains unclear. Distribution, Fourier and algorithmic analyses confirmed that the pregnancy-induced increase in circulating GH in 3-week pregnant rats was due to a 13-fold increase in baseline circulating GH (P < 0.01), without any significant alteration in the parameters of episodic secretion. Electron microscopy revealed that pregnancy resulted in a reduction in the proportion of mammosomatotrophs (P < 0.01) and an increase in type II lactotrophs (P < 0.05), without any significant change in the somatotroph population. However, the density of the secretory granules in somatotrophs from 3-week pregnant rats was reduced (P < 0.05), and their distribution markedly polarised; the granules being grouped nearest the vasculature. Pituitary GH content was not increased, but steady-state GH mRNA levels declined progressively during pregnancy (P < 0.05). In situ hybridisation revealed that pregnancy was accompanied by a suppression of GH-releasing hormone mRNA expression in the arcuate nuclei (P < 0.05) and enhanced somatostatin mRNA expression in the periventric...Continue Reading

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Citations

May 5, 2009·Progress in Lipid Research·Timothy Wells
Jul 10, 2019·The Journal of Nutrition·Thomas W TilstonTimothy Wells
Sep 4, 2019·American Journal of Physiology. Endocrinology and Metabolism·Pryscila D S TeixeiraJose Donato
Oct 2, 2020·Journal of Neuroendocrinology·Papillon GustafsonDavid R Grattan
Jul 3, 2008·Current Opinion in Endocrinology, Diabetes, and Obesity

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