The prejunctional actions of some non-depolarizing blocking drugs

British Journal of Pharmacology
L C Blaber


1. Trains of end-plate potentials (e.p.p.s) have been recorded from the isolated tenuissimus of the cat. The muscle was paralyzed either by transversely cutting the muscle fibres or by non-depolarizing blocking drugs.2. The following parameters of transmitter synthesis, storage and release have been calculated: the quantal content of the first e.p.p. in the train, the size of the available store, fractional release, quantum size, and the rate of refilling of the available store.3. Tubocurarine and benzoquinonium depressed the rate of refilling of the available store causing its depletion at high rates of stimulation. This was offset by an increase in fractional release, which in the case of tubocurarine was sufficient for the quantal content of the first e.p.p. to be unchanged.4. Dimethyltubocurarine and pancuronium had a similar effect to tubocurarine on the rate of refilling of the store and depletion of the store at high rates of stimulation but did not increase fractional release. There was, therefore, a decrease in the quantal content of the first e.p.p.5. Lignocaine depressed the rate of refilling of the store and depleted the store at high rates of stimulation. Fractional release was also depressed.6. It is suggested tha...Continue Reading


Nov 1, 1972·British Journal of Pharmacology·L C Blaber
Jan 1, 1972·Proceedings of the Society for Experimental Biology and Medicine·S D GergisJ P Long
Mar 1, 1968·The Journal of Physiology·B KATZ, R MILEDI
Dec 1, 1968·The Journal of General Physiology·R I BirksD R Firth
Aug 2, 1969·Nature·J I HubbardM Miyamoto
Mar 1, 1971·Journal of Neurophysiology·A Galindo
Mar 1, 1971·The Journal of Physiology·A Auerbach, W J Betz
Aug 1, 1971·The Journal of Physiology·K Kuba, T Tomita
Jul 9, 1968·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·R I Birks, M W Cohen
Jan 1, 1971·Pflügers Archiv : European journal of physiology·H Bauer
Oct 15, 1967·The Japanese Journal of Physiology·C C ChangT F Chen
Nov 1, 1967·International Journal of Neuropharmacology·L C Blaber, D D Christ
Jun 1, 1965·The Journal of Physiology·D Elmqvist, D M Quastel
Jan 1, 1967·The Journal of Physiology·R Beránek, F Vyskocil
Jun 28, 1954·The Journal of Physiology·J DEL CASTILLO, B KATZ
May 1, 1959·The American Journal of Physiology·R E TAYLOR
Jun 1, 1961·Acta Physiologica Scandinavica·G LILLEHEIL, K NAESS
Feb 1, 1963·British Journal of Pharmacology and Chemotherapy·J G BLACKMAN
Nov 1, 1964·The Journal of Physiology·L BEANIF LEDDA
Feb 16, 1965·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·B KATZ, R MILEDI
May 4, 1936·The Journal of Physiology·H H DaleM Vogt


Sep 1, 1990·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·J R KambamB V Sastry
Mar 1, 1995·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·E P McCoyL D Paxton
Jul 1, 1992·Journal of Anesthesia·C LeeT Kubota
Jan 1, 1988·Trends in Pharmacological Sciences·W C BowmanA J Harborne
Jun 1, 1988·Clinical and Experimental Pharmacology & Physiology·A J HarborneI G Marshall
Jan 11, 2000·Pharmacology & Toxicology·M J de Oliveira, A C Oliveira
Nov 1, 1987·Acta Anaesthesiologica Scandinavica·F A WaliE J McAteer
Dec 1, 1995·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·C Prior, L Tian
Apr 1, 1989·Acta Anaesthesiologica Scandinavica·F M Gibson, R K Mirakhur
Nov 1, 1986·British Journal of Pharmacology·A J Gibb, I G Marshall

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