PMID: 6986269Jan 1, 1980Paper

The preleukemic syndromes (hematopoietic dysplasia) in childhood

European Journal of Pediatrics
E Kleihauer

Abstract

The preleukemic syndrome or hematopoietic dysplasia is a marrow stem-cell disorder with clinically recognizable hematologic abnormalities which precede the development of acute nonlymphocytic leukemia. Its occurrence in childhood is extremely rare; seven "true" cases who fulfill all the criteria for the disorder have been reported until now. The preleukemic syndrome is generally characterized by peripheral cytopenia with fairly specific morphologic abnormalities in cell differentiation. The hematological and clinical features permit recognition of preleukemia even before the development of overt leukemia. Experimental data indicate that preleukemia is an "early" leukemic syndrome in which hematopoietic cell differentiation becomes progressively impaired with termination in the nearly complete maturation block which is characteristic of acute myelogenous leukemia.

References

Mar 1, 1976·British Journal of Cancer·J S SennE A McCulloch
Aug 1, 1976·RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin·J WickenhauserG Hohenberg
Jul 1, 1977·British Journal of Haematology·D S Rosenthal, W C Moloney
Mar 1, 1978·British Journal of Haematology·J W Adamson, P J Fialkow
Aug 1, 1978·Cancer·J W Linman, G C Bagby
Aug 1, 1973·Archives of Internal Medicine·W B FisherR C Graham
Apr 27, 1973·Deutsche medizinische Wochenschrift·R GrossA Heller
Sep 1, 1972·British Journal of Haematology·J S Senn, P H Pinkerton
Feb 1, 1974·The Journal of Pediatrics·L G MacdougallJ M Judisch
Jan 1, 1968·Acta Haematologica·B E RobertsR D Pyrah
Dec 1, 1971·British Journal of Haematology·A Girolami
Dec 1, 1971·British Journal of Haematology·J R HumbertJ H Githens
Nov 1, 1965·American Journal of Diseases of Children·D L RandallA Robinson
Jun 3, 1971·The New England Journal of Medicine·P L GreenbergS L Schrier
Sep 1, 1970·Acta paediatrica Scandinavica·J Polák, J Zizka
Jul 11, 1953·Journal of the American Medical Association·M BLOCKW F BETHARD

❮ Previous
Next ❯

Citations

Feb 1, 1989·European Journal of Pediatrics·S O Lie
Mar 1, 1982·Cancer Genetics and Cytogenetics·P C Nowell
Oct 1, 1992·British Journal of Haematology·M A TuncerG J Mufti
May 1, 1994·Annals of Hematology·A VitaleF Mandelli
May 1, 1985·British Journal of Haematology·E R van WeringP M Theunissen
May 1, 1986·British Journal of Haematology·H G KlingemannE D Thomas
Jun 1, 1982·The Journal of Pediatrics·N L KobrinskyR D Brunning
Sep 15, 2016·Surgical Neurology International·Soheila Raysi DehcordiRenato J Galzio
Nov 4, 2010·Indian Journal of Pathology & Microbiology·Safoorah KhalidMohammad Khurshid
Jan 1, 1986·Scandinavian Journal of Haematology. Supplementum·R Wegelius
Jun 1, 1981·Human Pathology·P C Nowell

❮ Previous
Next ❯

Related Concepts

Related Feeds

Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a clinically and genetically heterogeneous disease with approximately 20,000 cases per year in the United States. AML also accounts for 15-20% of all childhood acute leukemias, while it is responsible for more than half of the leukemic deaths in these patients. Here is the latest research on this disease.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

AML: Role of LSD1 by CRISPR (Keystone)

Find the latest rersearrch on the ability of CRISPR-Cas9 mutagenesis to profile the interactions between lysine-specific histone demethylase 1 (LSD1) and chemical inhibitors in the context of acute myeloid leukemia (AML) here.