PMID: 13295487Mar 1, 1956

The preparation and function of the hypertensin-converting enzyme

The Journal of Experimental Medicine
L T SKEGGSN P SHUMWAY

Abstract

It has been shown by use of isolated, perfused rat kidneys that hypertensin II is a potent vasoconstrictor substance while hypertensin I is not. Hence it would appear that in intact animals the pressor activity of hypertensin I results from its rapid conversion to hypertensin II. An enzyme which effects this conversion has been procured from horse plasma in a semipurified form by means of ammonium sulfate fractionation and isoelectric precipitation. A method is described for estimating the activity of the enzyme. An example of the use of the preparation in converting purified hypertensin I to hypertensin II has been described.

References

Mar 1, 1954·The Journal of Experimental Medicine·L T SKEGGSN P SHUMWAY
Oct 1, 1955·The Journal of Experimental Medicine·L T SKEGGSN P SHUMWAY
Dec 1, 1949·Proceedings of the Society for Experimental Biology and Medicine·L T SKEGGSC R HEISLER

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