It has been shown by use of isolated, perfused rat kidneys that hypertensin II is a potent vasoconstrictor substance while hypertensin I is not. Hence it would appear that in intact animals the pressor activity of hypertensin I results from its rapid conversion to hypertensin II. An enzyme which effects this conversion has been procured from horse plasma in a semipurified form by means of ammonium sulfate fractionation and isoelectric precipitation. A method is described for estimating the activity of the enzyme. An example of the use of the preparation in converting purified hypertensin I to hypertensin II has been described.
TLC characterization of liposomes containing angiotensinogen, angiotensine I, angiotensine II and saralazin
Angiotensin I converting enzyme in human intestine and kidney. Ultrastructural immunohistochemical localization
Angiotensin converting enzyme inhibitors: comparative structure, pharmacokinetics, and pharmacodynamics
The effects of angiotensin-converting enzyme-inhibitory peptide LAP on the left common carotid artery remodeling in spontaneously hypertensive rats
Antihypertensive effect of angiotensin I-converting enzyme inhibitory peptides derived from hemoglobin
ACE-like hydrolysis of gastrin analogs and CCK-8 by fundic mucosal cells of different species with release of the amidated C-terminal dipeptide
Converting-enzyme in the choroid plexus, brain, and kidney: immunocytochemical and biochemical studies in rats
Biochemical and immunological studies of angiotensin converting enzymes from human, bovine, dog, hog, rabbit, rat and sheep kidneys
Kinetic and inhibitory characteristics of serum angiotensin-converting enzyme from nine mammalian species
Angiotensin II-producing proteases from granulomatous tissue reaction in mice infected with Schistosoma mansoni
Oral administration of peptides derived from bonito bowels decreases blood pressure in spontaneously hypertensive rats by inhibiting angiotensin converting enzyme
Effect of chloride and diamide on serum angiotensin I-converting enzyme activity from eight mammalian species
Catabolism of the hemoregulatory peptide N-Acetyl-Ser-Asp-Lys-Pro: a new insight into the physiological role of the angiotensin-I-converting enzyme N-active site
Angiotensin converting enzyme (ACE) and neprilysin hydrolyze neuropeptides: a brief history, the beginning and follow-ups to early studies
N-domain selectivity of angiotensin I-converting enzyme as assessed by structure-function studies of its highly selective substrate, N-acetyl-seryl-aspartyl-lysyl-proline
Nitric oxide donors and angiotensin-converting enzyme inhibitors act in concert to inhibit human angiotensin-converting enzyme activity and platelet aggregation in vitro
Angiotensin converting-like enzymes from urine of untreated renovascular hypertensive and normal patients: purification and characterization
Purification and characterization of a dipeptidyl carboxypeptidase from the polychaete Neanthes virens resembling angiotensin I converting enzyme
Aminopeptidase A: distribution in rat brain nuclei and increased activity in spontaneously hypertensive rats
Peptide inhibitors for angiotensin I-converting enzyme from enzymatic hydrolysates of porcine skeletal muscle proteins
Activation of vascular tissue angiotensin-converting enzyme (ACE) in heart failure. Effects of ACE inhibitors
The role of Angiotensin-converting enzyme in blood pressure control, renal function, and male fertility
Angiotensin converting enzymes from human urine of mild hypertensive untreated patients resemble the N-terminal fragment of human angiotensin I-converting enzyme
Purification of angiotensin I converting enzyme from pig lung using concanavalin-A sepharose chromatography
Maternal low-protein diet during mouse pre-implantation development induces vascular dysfunction and altered renin-angiotensin-system homeostasis in the offspring
Hypotensive and heart rate-lowering effects in rats receiving milk fermented by specific Lactococcus lactis strains
Inhibitor and substrate binding by angiotensin-converting enzyme: quantum mechanical/molecular mechanical molecular dynamics studies
Multifunctional properties of soy milk fermented by Enterococcus faecium strains isolated from raw soy milk
Inactivation of human angiotensin converting enzyme by copper peptide complexes containing ATCUN motifs
Novel activity of human angiotensin I converting enzyme: release of the NH2- and COOH-terminal tripeptides from the luteinizing hormone-releasing hormone
Purification of an angiotensin II binding protein by using antibodies to a peptide encoded by angiotensin II complementary RNA
Reverse transcription polymerase chain reaction (RT-PCR) analysis of proteolytic enzymes in cultures of human respiratory epithelial cells
Effect of casein hydrolysate, prepared with protease derived from Aspergillus oryzae, on subjects with high-normal blood pressure or mild hypertension
Health benefits of traditional corn, beans, and pumpkin: in vitro studies for hyperglycemia and hypertension management
Relationship between plasma concentrations of angiotensin I, angiotensin II and plasma renin activity during cardio-pulmonary bypass in man
Effect of inhibitors on the coordination geometries of cadmium at the metal sites in angiotensin-I-converting enzyme
A modern understanding of the traditional and nontraditional biological functions of angiotensin-converting enzyme
Angiotensin I-converting enzyme inhibitors are allosteric enhancers of kinin B1 and B2 receptor function
Inhibition of angiotensin-converting enzyme activity by flavonoids: structure-activity relationship studies
Novel ketomethylene inhibitors of angiotensin I-converting enzyme (ACE): inhibition and molecular modelling
Association of urinary N-domain Angiotensin I-converting enzyme with plasma inflammatory markers and endothelial function
Angiotensin-I-converting enzyme (ACE) inhibitors from marine resources: prospects in the pharmaceutical industry
High glucose activates the alternative ACE2/Ang-(1-7)/Mas and APN/Ang IV/IRAP RAS axes in pancreatic β-cells
Coumarin-Ser-Asp-Lys-Pro-OH, a fluorescent substrate for determination of angiotensin-converting enzyme activity via high-performance liquid chromatography
Discovery of new angiotensin converting enzyme (ACE) inhibitors from medicinal plants to treat hypertension using an in vitro assay
Role of angiotensin in ovarian follicular development and ovulation in mammals: a review of recent advances
Novel angiotensin I-converting enzyme inhibitory peptides found in a thermolysin-treated elastin with antihypertensive activity
Restriction of the in vitro formation of angiotensin II by leucinyl-arginyl-tryptophan, a novel peptide with potent angiotensin I-converting enzyme inhibitory activity
Mouse embryo culture induces changes in postnatal phenotype including raised systolic blood pressure
Enhancement or Suppression of ACE Inhibitory Activity by a Mixture of Tea and Foods for Specified Health Uses (FOSHU) That Are Marketed as "Support for Normal Blood Pressure"
Cloning and sequence analysis of a Bothrops jararaca cDNA encoding a precursor of seven bradykinin-potentiating peptides and a C-type natriuretic peptide
Nine novel angiotensin I-converting enzyme (ACE) inhibitory peptides from cuttlefish (Sepia officinalis) muscle protein hydrolysates and antihypertensive effect of the potent active peptide in spontaneously hypertensive rats
Identification of prolyl carboxypeptidase as an alternative enzyme for processing of renal angiotensin II using mass spectrometry
Thermodynamic determination of the binding constants of angiotensin-converting enzyme inhibitors by a displacement method
High degree of conversion of angiotensin I to angiotensin II in the mesenteric circulation of the isolated perfused terminal ileum of the cat
Insight into the interactive residues between two domains of human somatic Angiotensin-converting enzyme and Angiotensin II by MM-PBSA calculation and steered molecular dynamics simulation
Heterogeneous distribution of angiotensin I-converting enzyme (CD143) in the human and rat vascular systems: vessel, organ and species specificity
Trilogy of ACE2: a peptidase in the renin-angiotensin system, a SARS receptor, and a partner for amino acid transporters
Purification and identification of proteolytic enzymes from Aspergillus oryzae capable of producing the antihypertensive peptide Ile-Pro-Pro
Angiotensin processing is partially carried out by carboxypeptidases in the rat mesenteric arterial bed perfusate
Catalytic properties of recombinant dipeptidyl carboxypeptidase from Escherichia coli: a comparative study with angiotensin I-converting enzyme
Purification and characterization of an endopeptidase that has an important role in the carboxyl terminal processing of antihypertensive peptides in Lactobacillus helveticus CM4
Isolation and identification of antihypertensive peptides from antarctic krill tail meat hydrolysate
Residues affecting the chloride regulation and substrate selectivity of the angiotensin-converting enzymes (ACE and ACE2) identified by site-directed mutagenesis
A novel bradykinin potentiating peptide isolated from Bothrops jararacussu venom using catallytically inactive oligopeptidase EP24.15
Zingiber officinale extract exhibits antidiabetic potential via modulating glucose uptake, protein glycation and inhibiting adipocyte differentiation: an in vitro study
The pharmacological mechanism of angiotensin-converting enzyme inhibition by green tea, Rooibos and enalaprilat - a study on enzyme kinetics
Effects of eNOS rs1799983 and ACE rs4646994 polymorphisms on the therapeutic efficacy of salvianolate injection in Chinese patients with coronary heart disease
Crystal structures of highly specific phosphinic tripeptide enantiomers in complex with the angiotensin-I converting enzyme
The ontogeny of human pulmonary angiotensin-converting enzyme and its aberrant expression may contribute to the pathobiology of bronchopulmonary dysplasia (BPD)
Kinetic and structural characterisation of amyloid-β peptides hydrolysis by human angiotensin-1-converting enzyme
Purification and identification of angiotensin converting enzyme inhibitory peptides from beef hydrolysates
Identification of five new bradykinin potentiating peptides (BPPs) from Bothrops jararaca crude venom by using electrospray ionization tandem mass spectrometry after a two-step liquid chromatography
Interactions of the systemic and brain renin-angiotensin systems in the control of drinking and the central mediation of pressor responses
Receptors for angiotensins I and II: their relevance to renal haemodynamics, blood pressure control and hind-limb blood flow
Determination of angiotensin I-converting enzyme activity in cell culture using fluorescence resonance energy transfer peptides
Angiotensin-I converting enzyme (ACE): structure, biological roles, and molecular basis for chloride ion dependence
Angiotensin-converting enzyme inhibitors of Bothrops jararaca snake venom affect the structure of mice seminiferous epithelium
Characterization of domain-selective inhibitor binding in angiotensin-converting enzyme using a novel derivative of lisinopril
Angiotensin-degrading serine peptidase: a new chymotrypsin-like activity in the venom of Bothrops jararaca partially blocked by the commercial antivenom
Expression of angiotensin-converting enzyme gene in whole blood in patients with essential hypertension
Identification of snake bradykinin-potentiating peptides (BPPs)-simile sequences in rat brain--Potential BPP-like precursor protein?
Inhibitory effect of αS1- and αS2-casein hydrolysates on angiotensin I-converting enzyme in human endothelial cells in vitro, rat aortic tissue ex vivo, and renovascular hypertensive rats in vivo
LC-MS/MS coupled with QSAR modeling in characterising of angiotensin I-converting enzyme inhibitory peptides from soybean proteins
Isolation, identification and molecular docking studies of a new isolated compound, from Onopordon acanthium: a novel angiotensin converting enzyme (ACE) inhibitor
Three key proteases--angiotensin-I-converting enzyme (ACE), ACE2 and renin--within and beyond the renin-angiotensin system
Cardioprotective cryptides derived from fish and other food sources: generation, application, and future markets
Characterization of angiotensin I-converting enzyme from anterior gills of the mangrove crab Ucides cordatus
Purification and characterisation of a novel angiotensin-I converting enzyme (ACE)-inhibitory peptide derived from the enzymatic hydrolysate of Enteromorpha clathrata protein
Fast high-throughput screening of angiotensin-converting enzyme insertion/deletion polymorphism by variable programmed electric field strength-based microchip electrophoresis
Purification and characterization of angiotensin I converting enzyme inhibitory peptides from the rotifer, Brachionus rotundiformis
Optimization of polysaccharides extraction from watermelon rinds: Structure, functional and biological activities
Structure, evolutionary conservation, and functions of angiotensin- and endothelin-converting enzymes
Angiotensin II reverses the inhibitory action produced by theca cells on bovine oocyte nuclear maturation
Association between polymorphisms of the angiotensin-converting enzyme and angiotensinogen genes and allergic rhinitis in a Korean population
Substrate binding properties of converting enzyme using a series of p-nitrophenylalanyl derivatives of angiotensin I
The use of Fluorescence Resonance Energy Transfer (FRET) peptides for measurement of clinically important proteolytic enzymes
A continuous fluorescent assay for the determination of plasma and tissue angiotensin I-converting enzyme activity
A calorimetric study of the binding of lisinopril, enalaprilat and captopril to angiotensin-converting enzyme
Antioxidant and ACE enhancing potential of Pankajakasthuri in fluoride toxicity: an in vitro study on mammalian lungs
Optimization of Goat Milk with ACE Inhibitory Peptides Fermented by Lactobacillus bulgaricus LB6 Using Response Surface Methodology
Identification of an ACE-Inhibitory Peptide from Walnut Protein and Its Evaluation of the Inhibitory Mechanism
Purification of angiotensin-converting enzyme from human plasma and investigation of the effect of some active ingredients isolated from Nigella sativa L. extract on the enzyme activity
Crystal structures of sampatrilat and sampatrilat-Asp in complex with human ACE - a molecular basis for domain selectivity
Characterization of the angiotensin-converting enzyme inhibitory activity of fermented milks produced with Lactobacillus casei
The hemoregulatory peptide N-acetyl-Ser-Asp-Lys-Pro is a natural and specific substrate of the N-terminal active site of human angiotensin-converting enzyme.
Structural characterization of a diuretic peptide from the central nervous system of the leech Erpobdella octoculata. Angiotensin II Amide.
Drying Methods Alter Angiotensin-I Converting Enzyme Inhibitory Activity, Antioxidant Properties, and Phenolic Constituents of African Mistletoe (Loranthus bengwensis L) Leaves
Effect of ingesting sour milk fermented using Lactobacillus helveticus bacteria producing tripeptides on blood pressure in subjects with mild hypertension
Hemorphins derived from hemoglobin have an inhibitory action on angiotensin converting enzyme activity
Analogues containing the paramagnetic amino acid TOAC as substrates for angiotensin I-converting enzyme
Zinc binding in peptide models of angiotensin-I converting enzyme active sites studied through 1H-NMR and chemical shift perturbation mapping
Renal pressor system in hypertension; evidence for circulating hypertensin in chronic renal hypertension; nature and activity of purified hypertensin
Improved assay methods for renin "concentration" and "activity" in human plasma. Methods using selective denaturation of renin substrate
A DNA variant at the angiotensin-converting enzyme gene locus associates with coronary artery disease in the Caerphilly Heart Study
Inhibition of human peptidyl dipeptidase (angiotensin I converting enzyme: kininase II) by human serum albumin and its fragments
Angiotensin-converting enzyme gene polymorphism has no influence on the circulating renin-angiotensin-aldosterone system or blood pressure in normotensive subjects
Angiotensin I converting enzyme and the changes in our concepts through the years. Lewis K. Dahl memorial lecture
Characterization of angiotensin-converting enzyme inhibitory activity of fermented milk produced by Lactobacillus helveticus
Expression, purification, and physicochemical characterization of the N-terminal active site of human angiotensin-I converting enzyme
Short communication: bovine kappa-casein variants result in different angiotensin I converting enzyme (ACE) inhibitory peptides
Angiotensin-converting enzyme inhibitory activity of milk fermented by wild and industrial Lactococcus lactis strains
Antihypertensive effect of sour milk and peptides isolated from it that are inhibitors to angiotensin I-converting enzyme
Development of a fast liquid chromatography/mass spectrometry screening method for angiotensin-converting enzyme (ACE) inhibitors in complex natural mixtures like snake venom
A phytochemical in the edible Tamogi-take mushroom (Pleurotus cornucopiae), D-mannitol, inhibits ACE activity and lowers the blood pressure of spontaneously hypertensive rats
Putting microbes to work: dairy fermentation, cell factories and bioactive peptides. Part II: bioactive peptide functions
Angiotensin converting enzyme insertion/deletion polymorphism and renoprotection in diabetic and nondiabetic nephropathies
Angiotensin I-converting enzyme inhibitory peptides derived from bovine casein and identified by MALDI-TOF-MS/MS
Potentiation of des-Arg9-kallidin-induced vasoconstrictor responses by metallopeptidase inhibition in isolated human umbilical artery
Purification and characterization of angiotensin I-converting enzymes from mesangial cells in culture
A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase
Diverse cell surface protein ectodomains are shed by a system sensitive to metalloprotease inhibitors.
Evaluation of Tenebrio molitor protein as a source of peptides for modulating physiological processes
Sex-Specific Modulation of Blood Pressure and the Renin-Angiotensin System by ACE (Angiotensin-Converting Enzyme) 2
Molecular docking, molecular dynamics simulations and reactivity, studies on approved drugs library targeting ACE2 and SARS-CoV-2 binding with ACE2
ACE inhibition enhances bradykinin relaxations through nitric oxide and B1 receptor activation in bovine coronary arteries
Discovery and characterization of ACE2 - a 20-year journey of surprises from vasopeptidase to COVID-19.
Determination of the angiotensinase-(aminopeptidase-)activity in blood using a DPN. H-dependent optical test
Sustained antihypertensive effect of captopril combined with diuretics and beta-adrenergic blocking drugs in patients with resistant hypertension
Effect of peptide-based captopril analogues on angiotensin converting enzyme activity and peroxynitrite-mediated tyrosine nitration
Identification of novel inhibitors of dipeptidylcarboxypeptidase of Leishmania donovani via ligand-based virtual screening and biological evaluation
Two Novel Bioactive Peptides from Antarctic Krill with Dual Angiotensin Converting Enzyme and Dipeptidyl Peptidase IV Inhibitory Activities
Correlation between angiotensin-converting enzyme activity and histologic patterns in benign prostatic hypertrophy tissue
Different glycosylation requirements for the synthesis of enzymatically active angiotensin-converting enzyme in mammalian cells and yeast.
Effect of synthetic hypertensin II on PAH- and inulin clearance, on renal hemodynamics and on diuresis in man
Studies on the effect of synthetic hypertensin II on blood pressure, respiration and blood circulation of extremities in man
Novel Therapeutic Approaches Targeting the Renin-Angiotensin System and Associated Peptides in Hypertension and Heart Failure
Bifunctional peptides with antioxidant and angiotensin-converting enzyme inhibitory activity in vitro from egg white hydrolysates
Lack of association between ACE gene polymorphisms and atopy and asthma in British and Japanese populations
Optimization of Nutrient Composition for Producing ACE Inhibitory Peptides from Goat Milk Fermented by Lactobacillus bulgaricus LB6
The Controversy of Renin-Angiotensin-System Blocker Facilitation Versus Countering COVID-19 Infection.
Antidiabetic Food-Derived Peptides for Functional Feeding: Production, Functionality and In Vivo Evidences
Evaluation of a simple colorimetric assay for serum angiotensin-converting enzyme: comparison with a new ion-pair liquid chromatography-assisted assay
Bioinformatic characterization of angiotensin-converting enzyme 2, the entry receptor for SARS-CoV-2
ACE2 and ACE: structure-based insights into mechanism, regulation and receptor recognition by SARS-CoV.
What would Sérgio Ferreira say to your physician in this war against COVID-19: How about kallikrein/kinin system?
Cardiovascular implications and complications of the coronavirus disease-2019 pandemic: a world upside down.
Edible Microalgae and Their Bioactive Compounds in the Prevention and Treatment of Metabolic Alterations.
Effects of Fermented Edible Seeds and Their Products on Human Health: Bioactive Components and Bioactivities
Quantitative Proteomic Analysis of the Slime and Ventral Mantle Glands of the Striped Pyjama Squid (Sepioloidea lineolata )
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