The preparation, cytocompatibility, and in vitro biodegradation study of pure beta-TCP on magnesium.

Journal of Materials Science. Materials in Medicine
F GengKe Yang

Abstract

Biodegradable and bioactive beta-tricalcium phosphate (beta-TCP) coatings were prepared on magnesium (Mg) in order to improve its biocompatibility by a chemical method. The tensile bonding strength of beta-TCP coating and Mg substrate was measured by the standard adhesion test (ISO 13779-4). And the cytocompatibility of beta-TCP coated Mg was studied by using human osteoblast-like MG63 cells. It was found that the MG63 cells could grow well on the surface of beta-TCP coated Mg and the cell viability on beta-TCP coated Mg was above 80% during the cocultivation of MG63 cells and beta-TCP coated Mg for 10 days, indicating no cytotoxicity. It was concluded that the beta-TCP coated Mg had good cytocompatibility. The degradation of Mg substrate with beta-TCP coating in vitro was studied in detail by XRD, EDX, SEM, and ICP. The results showed that a bone-like apatite continually formed on the surface of the sample with the degradation of both Mg substrate and beta-TCP coating in Hank's solution (a simulated body fluid). The biodegradation mechanism was preliminarily analyzed in the paper.

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Citations

Sep 13, 2011·Journal of Materials Science. Materials in Medicine·Ji-Hoon JoYoung-Hag Koh
Sep 8, 2012·International Journal of Nanomedicine·Qian WangJing Liu
Mar 13, 2014·Acta Biomaterialia·Sergey V Dorozhkin
May 16, 2015·International Journal of Molecular Medicine·Yi LiaoXinling Wang
May 9, 2012·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Jiali WangLing Qin
Nov 3, 2011·Journal of Biomedical Materials Research. Part a·Hongwei ChaiKe Yang
Jan 28, 2016·Regenerative Biomaterials·Peng Tian, Xuanyong Liu
Jan 7, 2017·The Journal of Craniofacial Surgery·Soo-Hwan ByunJong-Ho Lee
Nov 6, 2010·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Sigrid KeimSannakaisa Virtanen
Feb 13, 2020·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Soo-Hwan ByunJong-Ho Lee
Aug 31, 2015·Materials·Zeeshan SheikhMichael Glogauer
Dec 13, 2019·BioMed Research International·Xufang ZhangXueli Mao
Feb 11, 2011·The International Journal of Artificial Organs·Stephan SchumacherManfred Kietzmann
Nov 12, 2020·Military Medical Research·Shuai WeiXin-Long Ma

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