The Presence and Extension of Myocardial Fibrosis in the Undetermined Form of Chagas' Disease: A Study Using Magnetic Resonance

Arquivos brasileiros de cardiologia
Márcia Maria Noya-RabeloLuís Claudio Lemos Correia

Abstract

Previous data has shown that patients in the indeterminate form of Chagas disease may present myocardial fibrosis as shown on through magnetic resonance imaging (MRI). However, there is little information available regarding the degree of severity of myocardial fibrosis in these individuals. This variable has the potential to predict the evolution of Chagas' disease into its cardiac form. To describe the frequency and extent of myocardial fibrosis evaluated using an MRI in patients in the indeterminate form, and to compare it with other forms of the disease. Patients were admitted one after another. Their clinical history was collected and they were submitted to laboratory exams and an MRI. Sixty-one patients with Chagas' disease, with an average age of 58 ± 9 years old, 17 patients in the indeterminate form, 16 in the cardiac form without left ventricular (LV) dysfunction and 28 in the cardiac form with LV dysfunction were studied. P <0.05 was considered to be statistically significant. Late enhancement was detected in 37 patients (64%). Myocardial fibrosis was identified in 6 individuals in indeterminate form (41%; 95% CI 23-66) in a proportion similar to that observed in cardiac form without LV dysfunction (44%); p = 1.0. Am...Continue Reading

Citations

Oct 5, 2019·Cardiology Research and Practice·Andrés DiazJosep Brugada
Jul 3, 2020·The International Journal of Cardiovascular Imaging·Alejandro Duran-CraneHector M Medina
May 1, 2021·Pathogens·Antonia Pino-MarínHector M Medina

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