The presence and impact of diastolic dysfunction on physical function and body composition in hemodialysis patients

Journal of Nephrology
Jin Hee JeongKenneth Robert Wilund

Abstract

Cardiovascular (CV) diseases are the main cause of death in maintenance hemodialysis (MHD) patients. Muscle wasting and physical function decline are common in MHD patients, and significantly impair their quality of life. These can result from abnormalities in cardiac function, which can be further worsened by physical deconditioning. Left ventricular diastolic function parameters were recently shown to be a better predictor of exercise capacity than systolic measures in patients with CV complications. But little is known about the relationship between cardiac function and physical function in MHD patients. In 82 MHD patients, left ventricular systolic dysfunction (LVSD) was assessed by ejection fraction and fractional shortening with echocardiography, and left ventricular diastolic dysfunction (LVDD) was assessed by pulse wave and tissue Doppler indices. Physical function was assessed by gait speed, performance on a shuttle walk test, and leg muscle strength. Dual-emission X-ray absorptiometry (DXA) was used to measure whole body lean mass (WBLM). The prevalence of LVDD and LVSD was 48.8 and 12.2%, respectively. Gait speed, shuttle walk time, leg strength, and WBLM% were significantly higher in the group without LVDD than with...Continue Reading

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Citations

Jan 27, 2017·Geriatrics & Gerontology International·Tetsuya TakahashiHideki Ito
May 17, 2019·The International Journal of Cardiovascular Imaging·Mads ErsbøllKasper Iversen
Mar 8, 2019·BMC Nephrology·Damiano D ZempEling D de Bruin

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