The presence of beta-lactamase-producing bacteria as a guideline in the management of children with recurrent tonsillitis

American Journal of Otolaryngology
I Brook

Abstract

Thirty-eight children who had recurrent tonsillitis and who were chronic carriers of group A beta-hemolytic streptococci (GABHS) were treated with oral clindamycin. Surface tonsillar cultures, obtained prior to therapy and two weeks after the termination of therapy, were processed for aerobic and anaerobic microorganisms. Mixed aerobic and anaerobic flora were obtained from all cultures. Prior to therapy, the average yield was 9.3 isolates (5.2 aerobes and 4.1 anaerobes) per specimen; after the completion of therapy, the average yield was 5.5 isolates (3.0 aerobes and 2.5 anaerobes). The GABHS were completely eliminated after clindamycin therapy, and the numbers of isolates of Bacteroides spp and Staphylococcus aureus were reduced. Beta-lactamase production was detected prior to therapy in 57 isolates recovered from all tonsillar surfaces. This group included all isolates of S. aureus (15) and Bacteroides fragilis (eight), 19 of 34 Bacteroides melaninogenicus isolates (56 per cent), and seven of 12 Bacteroides oralis isolates (58 per cent). Only four isolates of beta-lactamase-producing bacterial strains were recovered after the conclusion of therapy. Follow-up study of 33 children for eight to 16 months (average, 13 months) sh...Continue Reading

References

May 1, 1975·Antimicrobial Agents and Chemotherapy·A S Hackman, T D Wilkins
Mar 1, 1975·Antimicrobial Agents and Chemotherapy·C A RotilieR L Perkins
Dec 1, 1980·The Journal of Pediatrics·G FleisherE Lennette
May 1, 1981·The Annals of Otology, Rhinology, and Laryngology·I BrookE M Friedman

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Citations

Jun 1, 1995·The American Journal of Medicine·S M Retchin, R E Hurley
Dec 31, 1986·The American Journal of Medicine·M V Pauly
Jan 1, 1987·Journal of Chronic Diseases·J E Ware
Oct 1, 1991·Clinical Otolaryngology and Allied Sciences·J H Jensen, S B Larsen
Nov 1, 1992·Acta Oto-laryngologica·T Ovesen, J D Börglum
Jan 1, 1990·Critical Reviews in Biochemistry and Molecular Biology·K M Takayama, M Inouye

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