The presence of beta2 microglobulin on the membrane of the keratinocyte in premalignant skin disorders

The British Journal of Dermatology
H R Vinninghe, H A Neumann

Abstract

Beta2 Microglobulin, the invariable light chain of the histocompatibility antigen, has proved to be absent on the cell surface of basal cell carcinoma. In actinically damaged skin and in patients with a past history of arsenic ingestion changes can be observed on the epidermal cell membrane which can predict malignancy before cell dysregulation is visible. The epidermis in the basal cell naevus syndrome behaves in this respect as normal epidermis and the spontaneous tumour growth cannot be explained by a predisposing defect in the HLA-antigens of the epidermal cell surface.

References

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Citations

Jan 1, 1988·Archives of Dermatological Research·M BradbeerR Marks
Mar 20, 1982·Lancet·A Mashberg
Dec 1, 1981·Journal of the American Academy of Dermatology·M V Dahl
Apr 1, 1990·Journal of Cutaneous Pathology·A C MarkeyD M MacDonald
Oct 1, 1983·The Journal of Dermatology·M Furue, Y Inoue
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Jul 1, 1983·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section A, Pathology·M Kallioinen, K Dammert
Dec 1, 1986·The Journal of Urology·G R WaltonS D Graham

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Carcinoma, Basal Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.