The presence of cerebral and/or systemic endothelial dysfunction in patients with leukoaraiosis--a case control pilot study

BMC Neurology
Matija ZupanBojana Žvan

Abstract

In spite of high prevalence and clinical relevance of leukoaraiosis (LA), its pathophysiology is still incompletely understood. Theories of ischaemic genesis and a leaky blood-brain barrier are contradictory yet could share a common denominator-endothelial dysfunction (cerebral, systemic or both), which has not been studied thoroughly in LA. Thirty patients with LA (58 years (SD 7)) and 30 gender- and age-matched controls without LA (55 years (SD 6)) were recruited. The vascular risk factors (VRF) were identical in both groups. Cerebral endothelial function was determined by cerebrovascular reactivity to L-arginine (CVR). Systemic endothelial function was determined by flow-mediated dilatation (FMD) of the brachial artery after hyperaemia. All participants underwent a brain MRI to search for radiological signs of LA that was classified according to the Fazekas score. Linear regression was used to explore the correlation between CVR and FMD in patients with LA. A 95 % confidence interval was used. For any statistical test used in the study, p ≤ 0.050 was regarded as statistically significant. We found a marked and significant decrease in both CVR (9.6 % (SD 3.2) vs. 15.8 % (SD 6.1), p < 0.001) and FMD (4.8 % (SD 3.1) vs. 7.4 % (...Continue Reading

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Oct 6, 2016·Clinical and Experimental Pharmacology & Physiology·William K KarlssonChristina Kruuse
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Jul 8, 2021·The European Journal of Neuroscience·Aarushi RastogiSonu Menachem Maimonides Bhaskar
Aug 1, 2021·The European Journal of Neuroscience·Xiaojia TangYingzhu Chen

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