The presence of hypothermia within 24 hours of sepsis diagnosis predicts persistent lymphopenia

Critical Care Medicine
Anne M DrewryRichard S Hotchkiss

Abstract

To determine whether hypothermia within 24 hours of sepsis diagnosis is associated with development of persistent lymphopenia, a feature of sepsis-induced immunosuppression. Retrospective cohort study. A 1,200-bed university-affiliated tertiary care hospital. Adult patients diagnosed with bacteremia and sepsis within 5 days of hospital admission between January 1, 2010, and July 31, 2012. None. Leukocyte counts were recorded during the first 4 days following sepsis diagnosis. Persistent lymphopenia was defined as an absolute lymphocyte count less than 1.2 cells/μL×10(3) present on the fourth day after diagnosis. Of the 445 patients with sepsis included, hypothermia developed in 64 patients (14.4%) (defined as a body temperature<36.0°C) within 24 hours of sepsis diagnosis. Hypothermia was a significant independent predictor of persistent lymphopenia (adjusted odds ratio, 2.70 [95% CI, 1.10, 6.60]; p=0.03) after accounting for age, disease severity, comorbidities, source of bacteremia, and type of organism. Compared with the nonhypothermic patients, hypothermic patients had higher 28-day (50.0% vs 24.9%, p<0.001) and 1-year mortality (60.9% vs 47.0%, p=0.001). Hypothermia is associated with higher mortality and an increased risk ...Continue Reading

Associated Clinical Trials

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Citations

Feb 6, 2016·Future Microbiology·Orhan Rasid, Jean-Marc Cavaillon
May 16, 2015·Critical Care Medicine·James N Fullerton
Oct 16, 2015·Critical Care Medicine·Shouyin JiangXiaodi He
Oct 16, 2015·Critical Care Medicine·Anne M DrewryRichard S Hotchkiss
Dec 4, 2015·Intensive Care Medicine·Frédéric PèneRichard S Hotchkiss
Oct 16, 2016·Critical Care : the Official Journal of the Critical Care Forum·Maryse A WiewelW Joost Wiersinga
Dec 9, 2016·Journal of Forensic Sciences·Chong Zhou, Roger W Byard
Dec 3, 2016·Radiology and Oncology·Ksenija StrojnikBostjan Seruga
Jun 14, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Matthew LindebladDouglas L Feinstein
Feb 23, 2019·American Journal of Respiratory and Critical Care Medicine·Sivasubramanium V BhavaniMatthew M Churpek
Mar 9, 2019·American Journal of Respiratory and Critical Care Medicine·Hallie C Prescott
Jan 3, 2020·Therapeutic Hypothermia and Temperature Management·Ding-Ye Wu, Shi-Qi Lu
Mar 19, 2016·Journal of Applied Physiology·Monique T FonsecaAlexandre A Steiner
Aug 16, 2017·Annals of Intensive Care·Paola VilloisFabio Silvio Taccone
Apr 20, 2019·Orthopaedic Journal of Sports Medicine·Avinesh AgarwallaBrian Forsythe
Jul 2, 2020·Critical Care : the Official Journal of the Critical Care Forum·Takashi ShimazuiUNKNOWN JAAM FORECAST Group
Jan 12, 2017·Critical Care : the Official Journal of the Critical Care Forum·Alexandre A SteinerFrancisco G Soriano
Dec 31, 2020·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Satoshi YamagaNobuaki Shime
Aug 14, 2019·Cell·Harding H LuanRuslan Medzhitov
May 21, 2021·BMC Infectious Diseases·Chan-Wa CheongCheng-Yu Chien
Jun 11, 2021·Frontiers in Medicine·Yujing ZhangJiancheng Zhang

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