The presence of isolated tumor cells and micrometastases in the intrathoracic lymph nodes of patients with lung cancer is not associated with decreased survival

Human Pathology
Alberto M MarchevskyRobert J McKenna

Abstract

The prognostic role of small intrathoracic nodal metastases in primary patients with lung cancer has been controversial, and it is unclear how their presence should be used for pathologic staging and treatment planning. The intrathoracic lymph nodes from 266 clinical stage I non-small cell carcinoma patients treated at Cedars Sinai Medical Center from 1992 to 2006 were evaluated with immunohistochemistry for keratin AE1/AE3 for the presence of isolated tumor cells and micrometastases, as defined by American Joint Commission on Cancer criteria, correlated with survival using the Kaplan-Meier method and analyzed with power analysis. The English literature from 1995 to 2008 was reviewed to identify best available evidence regarding the prognostic value of isolated tumor cells and micrometastases detected with various immunohistochemistry and molecular methods in non-small cell carcinoma patients. Results were combined with our own data and evaluated with meta-analysis using Comprehensive Meta-analysis 2.0 software (Biostat Inc, Englewood, NJ). Isolated tumor cells and micrometastases were detected in 8 and 67 of 4148 lymph nodes, respectively, and their presence was not significantly associated with survival. Power analysis showed...Continue Reading

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Citations

Oct 29, 2011·Archives of Pathology & Laboratory Medicine·Mark R Wick, Alberto M Marchevsky
Oct 2, 2012·Archives of Pathology & Laboratory Medicine·Sanja Dacic
Oct 16, 2012·Seminars in Diagnostic Pathology·Gabriel L Sica, Anthony A Gal
Aug 24, 2013·Journal of Clinical Pathology·Catharine Ann DhaliwalWilliam A Wallace
Jun 19, 2016·Diagnostic Pathology·Ane Kongsgaard RudGunhild Mari Mælandsmo
Nov 24, 2011·Annals of Surgical Oncology·Mark B Faries, Donald L Morton
Feb 28, 2014·Virchows Archiv : an International Journal of Pathology·Per JönssonHans Brunnström
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