The presence of mature granulocytes/monocytes derived from leukemic cells in MLL-associated leukemia.

International Journal of Hematology
Shoichi KobayashiHeiwa Kanamori

Abstract

We observed the mature granulocytes/monocytes derived from leukemic cells in patients with acute myeloid leukemia who present mixed lineage leukemia gene (MLL). Morphologic observation and fluorescence in situ hybridization analysis (FISH) for chromosome 11q23 abnormality were studied, and a multiplex reverse transcriptase-polymerase chain reaction (RT-PCR) analysis was done to identify the fusion partners with MLL. The bone marrow cells with FISH signals of MLL showed the cell differentiation of the myeloid and/or monocytic lineages in 4 of 6 AML patients. MLL partner genes were AF6, AF9, ELL, and ENL, respectively. There was no correlation between the fusion partner and the appearance of mature cells derived from MLL clones. RT-PCR showed the fusion between MLL exon 9 or 10 and the partner genes in mature granulocytes/monocytes. These findings suggest that subgroup of leukemia cells with MLL rearrangement has the differentiation potential of leukemic cells and mature granulocytes/monocytes derived from MLL clones may be biologically different from normal mature cells.

References

Jun 10, 2000·British Journal of Haematology·C H Pui, M V Relling
May 4, 2005·Blood·Oliver TeuffelBeat W Schäfer
Feb 16, 2006·Cell Cycle·Sarah J Horton, Owen Williams
Mar 3, 2006·Leukemia·C MeyerR Marschalek
Jan 29, 2008·International Journal of Hematology·S Rodriguez-PeralesT H Rabbitts
Jan 29, 2008·International Journal of Hematology·Yali Dou, Jay L Hess

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