The presence of posttransplant HLA-specific IgG antibodies detected by enzyme-linked immunosorbent assay correlates with specific rejection pathologies

Transplantation
A N CostaV Bonomini

Abstract

Posttransplant monitoring of anti-HLA antibodies with routine techniques gives unsatisfactory results due to a variety of technical limitations. We investigated how a new alternative technique correlates with posttransplant clinical events. A total of 313 nonselected serum samples from 136 patients were screened by an ELISA utilizing captured soluble HLA class I antigens. We observed the absence of anti-HLA antibody production in acute rejection cases responding to standard antirejection therapy. On the other hand, we showed a clear presence of these antibodies in acute rejection episodes not responding to standard therapy (P<0.0001) and in chronic rejection (P<0.001). We conclude that routine posttransplant monitoring by ELISA offers early risk assessment that is crucial for proper immunosuppression and for antirejection therapy choice.

References

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Citations

Jun 7, 2005·Human Immunology·Sylvie Di FilippoAdriana Zeevi
Mar 27, 2001·Transplantation Proceedings·J E WorthingtonR W Johnson
May 16, 2002·Transplantation Proceedings·A C T TorrecilhasM Gerbase-DeLima
Sep 24, 1998·Transplantation Proceedings·R J Duquesnoy
May 29, 2003·Human Immunology·Marlies K A DankersFrans H J Claas
Jul 31, 1998·Human Immunology·J C McDonald, I Adamashvili
Aug 10, 1999·Human Immunology·L CarrodeguasA M VanBuskirk
Sep 23, 2003·Current Opinion in Immunology·Anna Valujskikh, Peter S Heeger
Jun 12, 2003·Transplant Immunology·Arnauld KaufmanEdison Régio de Moraes Souza
Dec 21, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Phillip RuizAndreas Tzakis
Apr 11, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Gema Fernández-FresnedoManuel Arias
Jan 1, 2015·Computational and Mathematical Methods in Medicine·Giovanni PallottiGaetano La Manna
Nov 18, 2008·Transplantation Proceedings·J PéfaurL Contreras
Mar 4, 2014·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Y-P JinE F Reed
Sep 27, 2005·Transplantation Proceedings·M MirelliA Stella
Dec 28, 1999·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·M MirelliM D'Addato
Dec 5, 2000·Baillière's Best Practice & Research. Clinical Haematology·C V Navarrete
Mar 24, 2000·Pediatric Transplantation·M P EmondsR Van Damme-Lombaerts
May 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yi-Ping JinElaine F Reed
Feb 29, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·C P YangE B Bell
Feb 6, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Peter T JindraElaine F Reed

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