The presence of prostacyclin binding sites in nonpregnant bovine uterine tissue

Prostaglandins, Leukotrienes, and Essential Fatty Acids
N Chegini, C V Rao

Abstract

Myometrium of various animal species makes a considerable amount of prostacyclin (PGI2) which is a potent myometrial and uterine vascular smooth muscle relaxing agent. This action of PGI2 is perhaps mediated by binding to specific receptors, which have never been demonstrated in uterine tissue of any animal species until very recently. The quantitative light microscopic autoradiographic approach used in the present studies demonstrated that while bovine myometrial smooth muscle and uterine vascular smooth muscle contained PGI2 specific binding sites, endometrial and perimetrial cells contained few or no binding sites. The number of binding sites in circular and elongated myometrial smooth muscle and in arteriolar smooth muscle were similar (P greater than 0.05). The PGI2 binding to the uterine cells was greatly reduced (P less than 0.001) following coincubation with excess unlabeled PGI2, but not with its stable metabolite, 6-keto PGF1 alpha, PGE2, PGF2 alpha and leukotriene C4 which bind to nonpregnant bovine uterine tissue, also had no effect of PGI2 binding. In conclusion, nonpregnant bovine uterine tissue contain specific PGI2 binding sites which may mediate its potent relaxing effect on myometrium and uterine vasculature.

References

Dec 1, 1976·Prostaglandins·N WhittakerF F Sun
Jan 1, 1979·Prostaglandins·C OminiF Berti
Sep 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·B B WekslerE A Jaffe
Feb 1, 1979·The Journal of Clinical Investigation·A M SieglD Ahern
Nov 1, 1979·Prostaglandins·M H Abel, R W Kelly
Jan 1, 1988·The Journal of Clinical Endocrinology and Metabolism·N Chegini, C V Rao
Apr 1, 1986·Prostaglandins, Leukotrienes, and Medicine·N CheginiJ Sanfilippo
Dec 1, 1981·Archives of Biochemistry and Biophysics·M E Carsten, J D Miller
Sep 1, 1980·Biochemical Pharmacology·E Schillinger, G Prior
Mar 1, 1981·British Journal of Pharmacology·I A Blair, J MacDermot
Jun 1, 1984·The Journal of Clinical Endocrinology and Metabolism·C V RaoG S Schultz
Nov 1, 1983·Prostaglandins·S J LyeJ R Challis
May 1, 1984·The Journal of Clinical Endocrinology and Metabolism·M C ReesA C Turnbull
Sep 1, 1982·Journal of Reproduction and Fertility·S J Lye, J R Challis
Sep 1, 1980·Journal of Reproduction and Fertility·N L Poyser, F M Scott
May 1, 1981·The Journal of Clinical Investigation·C Ingerman-WojenskiE Macarak
May 1, 1981·Journal of Reproduction and Fertility·R W Kelly

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