The presence of the ossific nucleus and its relation to avascular necrosis rates and the number of secondary procedures in late-presenting developmental dysplasia of the hip.

Journal of Pediatric Orthopedics. Part B
Michael ApostolidesRob H Richards

Abstract

Late-presenting developmental dysplasia of the hip (DDH) has an incidence reported between 0.07 and 2:1000 live births. Avascular necrosis (AVN) of the femoral head secondary to treatment of DDH is a feared complication and may lead to adverse long-term sequelae. This study aims to investigate the relationship between the ossific nucleus (ON) presence and AVN in late-presenting DDH. This is a retrospective study of prospectively collected data over a 24-year period, at a single UK centre. Late-presenting DDH who were treated surgically with a closed or open reduction were included in the series. The presence of ON was monitored, and outcomes measured included AVN and whether delaying surgery affected the number of secondary procedures. Seventy-six patients with 79 hips (mean age at presentation 13.8 months) were included in the analysis. The mean age at presentation was 13.8 months. About 45.5% of hips with no ON present developed clinically significant AVN (Kalamchi and MacEwen grades 2-4, P = 0.12), compared to 20.6% of hips with the ON present. Delaying surgery did not affect AVN rates or the number of secondary procedures. Looking at long-term outcomes, 86.7% of hips had a Severin grade of I or II and 13.3% had a grade ≥III...Continue Reading

References

Jan 6, 1999·The Journal of Bone and Joint Surgery. American Volume·S J LuhmannG S Bassett
Apr 3, 2009·The Journal of Bone and Joint Surgery. American Volume·Andreas RoposchMichael Dobson
Nov 9, 2010·Journal of Pediatric Orthopedics. Part B·Thomas AzzopardiAnnabelle Chan
Feb 12, 2011·Clinical Orthopaedics and Related Research·Andreas RoposchJohn H Wedge
Jun 3, 2015·The Bone & Joint Journal·S R Y W Thomas
Oct 17, 2015·Clinical Orthopaedics and Related Research·Eduardo N NovaisPatricia C Heyn
Dec 31, 2015·World Journal of Orthopedics·Pavel KotlarskyMark Eidelman
May 15, 2016·Journal of Children's Orthopaedics·Mathew D SchurPaul D Choi
Nov 5, 2016·Journal of Children's Orthopaedics·Catharine S BradleySimon P Kelley
Aug 30, 2018·Journal of Children's Orthopaedics·P CastañedaL Moscona-Mishy

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.