The Presence of Uveitis Is Associated with a Sustained Response to the Interleukin (IL)-1 Inhibitors Anakinra and Canakinumab in Behçet's Disease

Ocular Immunology and Inflammation
Claudia FabianiLuca Cantarini

Abstract

Purpose: To identify factors associated with sustained response to interleukin (IL)-1 inhibition among demographic, clinical and therapeutic data in patients with Behçet disease (BD).Methods: BD patients treated with anakinra or canakinumab were enrolled. Patients were divided into two groups according to the clinical response: group 1 included subjects showing a treatment duration of at least 52 weeks and no secondary inefficacy during the first follow-up year; the remaining patients were included in the group 2. Demographic, clinical and therapeutic data were analyzed to identify significant differences between groups.Results: Eighteen patients were included in group 1 and 18 patients in group 2. A better response to IL-1 inhibitors was significantly more common among patients with BD-related uveitis (p = 0.006) and patients with a longer disease duration (p = 0.03).Conclusion: IL-1 blockade is effective in BD, especially in the subset of patients presenting eye involvement and in those with long-lasting disease.

References

Oct 1, 2005·American Journal of Ophthalmology·Douglas A JabsUNKNOWN Standardization of Uveitis Nomenclature (SUN) Working Group
Mar 10, 2006·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·D RiganteA Stabile
Aug 20, 2008·Annals of Internal Medicine·Costantino BotsiosCharles A Dinarello
Jan 11, 2012·International Journal of Immunopathology and Pharmacology·L CantariniD Rigante
May 16, 2012·Annals of the Rheumatic Diseases·Serdal UgurluSebahattin Yurdakul
Apr 20, 2013·Rheumatic Diseases Clinics of North America·Gulen HatemiHasan Yazici
Aug 24, 2013·Mediators of Inflammation·Antonio VitaleLuca Cantarini
Oct 24, 2013·Clinical Rheumatology·Fereydoun DavatchiNegin Mohtasham
Dec 7, 2013·Clinical Rheumatology·Luca CantariniRolando Cimaz
Mar 20, 2014·Dermatology : International Journal for Clinical and Investigative Dermatology·Antonio VitaleLuca Cantarini
Jun 3, 2015·International Journal of Rheumatic Diseases·Antonio VitaleLuca Cantarini
Jul 15, 2015·Mediators of Inflammation·Yasuka MatsunagaTomoichiro Asano
Aug 28, 2015·Expert Review of Clinical Immunology·Isabelle Koné-Paut, Caroline Galeotti
Dec 9, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chi-Keung WanWarren J Leonard
May 11, 2016·Expert Opinion on Investigational Drugs·Antonio VitaleLuca Cantarini
Jun 24, 2016·International Journal of Dermatology·Giacomo EmmiDomenico Prisco
Dec 15, 2016·Turkish Journal of Medical Sciences·Hasan Yazıcı, Emire Seyahi
Jan 10, 2017·Expert Review of Clinical Immunology·Donato Rigante
Mar 16, 2017·Frontiers in Immunology·Giuseppe LopalcoFlorenzo Iannone
Jun 18, 2017·Internal and Emergency Medicine·Claudia FabianiLuca Cantarini

❮ Previous
Next ❯

Citations

Jul 24, 2020·Expert Review of Clinical Immunology·Carla GaggianoClaudia Fabiani
Sep 5, 2020·Expert Opinion on Drug Safety·Giuseppe LopalcoFlorenzo Iannone
Feb 13, 2019·Internal and Emergency Medicine·Emire Seyahi
Feb 26, 2019·Rheumatology International·Alessandra BettiolGiacomo Emmi
Jul 19, 2019·Internal and Emergency Medicine·Giacomo Emmi, Domenico Prisco
Jun 9, 2020·Mediators of Inflammation·Jurgen SotaClaudia Fabiani
Nov 5, 2020·Expert Opinion on Emerging Drugs·Ilknur Tugal-Tutkun, Pinar Çakar Özdal
Jan 23, 2021·Asia-Pacific Journal of Ophthalmology·Lisia Barros FerreiraJustine R Smith
Mar 13, 2021·Frontiers in Pharmacology·Hana MalcovaRudolf Horvath
Apr 6, 2021·Journal of Immunology Research·Kailei Guo, Xiaomin Zhang
Apr 16, 2021·International Journal of Immunopathology and Pharmacology·Silvia StefaniaFrancesco Paolo Cantatore
May 15, 2021·Experimental Eye Research·Qiuyun XuLiming Mao
May 21, 2021·Current Rheumatology Reports·Fatma Alibaz-Oner, Haner Direskeneli
Jun 3, 2021·Clinical Reviews in Allergy & Immunology·Jingjing Chen, Xu Yao
May 18, 2021·Frontiers in Medicine·Erkan AlpsoyShigeaki Ohno

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.