The presence of variant genotype of the mannose-binding lectin gene (MBL2) is not associated with increased restenosis rate in carotid surgery

Journal of Vascular Surgery
Wael AhmadJan Sigge Brunkwall

Abstract

We investigated the role of mannose-binding lectin (MBL) variant genotypes in patients with significant carotid restenosis after carotid endarterectomy (CEA) and who underwent a revision CEA. This was a cross-sectional analysis of 97 patients enrolled between 2001 and 2013. Three groups were investigated: group A included patients with internal carotid artery restenosis, group B included patients without restenosis after CEA, and group C included patients with peripheral arterial disease but without any signs of a carotid stenosis. Venous blood samples were drawn for the genotyping for MBL2 by polymerase chain reaction and for the determination of the MBL serum concentration by enzyme-linked immunoabsorbent assay. The serum concentration of MBL was higher in patients with the normal genotype than in those with the genotype variants of MBL (95% confidence interval, 272.8-1008.7 μg/L; P = .001). There was no statistically significant difference among groups A, B, or C with respect to the presence of a variant genotype. Similarly, there was no significant gender difference regarding the presence of a variant genotype (P = .325). The presence of a variant genotype of the MBL2 gene (and the correspondingly lower serum concentration ...Continue Reading

References

May 25, 1975·Journal of Molecular Biology·F Sanger, A R Coulson
Aug 15, 1991·The New England Journal of Medicine·UNKNOWN North American Symptomatic Carotid Endarterectomy Trial CollaboratorsM Eliasziw
Jan 1, 1991·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M W TurnerR J Levinsky
Nov 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·D A NickersonU Landegren
Nov 1, 1982·Archives of Surgery·R E ZierlerD E Strandness
Oct 6, 1997·The British Journal of Surgery·C R Lattimer, K G Burnand
Jan 28, 1998·Stroke; a Journal of Cerebral Circulation·H FrericksJ H van Bockel
Mar 21, 1998·Mammalian Genome : Official Journal of the International Mammalian Genome Society·N GuoK N Sastry
Aug 14, 2003·Molecular Immunology·Peter GarredClaus Koch
Mar 26, 2005·Stroke; a Journal of Cerebral Circulation·Szabolcs Rugonfalvi-KissPeter Garred
May 12, 2005·Journal of Vascular Surgery·Glenn M LaMuragliaRichard P Cambria
May 4, 2006·International Journal of Clinical Practice·H SadideenT S Padayachee
Oct 5, 2006·Annals of Vascular Surgery·Beate HuglAlbert G Hakaim

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