The present state of the tuberculosis drug development pipeline

Current Opinion in Pharmacology
M Daben J LibardoClifton E Barry

Abstract

Tuberculosis now ranks as the leading cause of death in the world due to a single infectious agent. Current standard of care treatment can achieve very high cure rates for drug-sensitive disease but requires a 6-month duration of chemotherapy. Drug-resistant disease requires significantly longer treatment durations with drugs associated with a higher risk of adverse events. Thus, there is a pressing need for a drug regimen that is safer, shorter in duration and superior to current front-line chemotherapy in terms of efficacy. The TB drug pipeline contains several candidates that address one or more of the required attributes of chemotherapeutic regimens that may redefine the standard of care of this disease. Several new drugs have been reported and novel targets have been identified allowing regimens containing new compounds to trickle into clinical studies. Furthermore, a recent paradigm-shift in understanding the pharmacokinetics of anti-tubercular drugs is revolutionizing the way we select compounds for clinical progression.

Citations

Jun 15, 2019·Journal of Cellular and Molecular Medicine·Xiaofei LiNiancai Peng
Jun 12, 2019·Antimicrobial Agents and Chemotherapy·Marissa Lindman, Thomas Dick
Jul 12, 2019·ChemMedChem·André CampaniçoFrancisca Lopes
Mar 4, 2020·BMJ : British Medical Journal·Anthony LeeRay Y Chen
Aug 7, 2019·Antimicrobial Agents and Chemotherapy·Yumi ParkHelena I Boshoff
Dec 15, 2019·Antibiotics·Jickky Palmae SarathyThomas Dick
Mar 11, 2020·Nature Reviews. Microbiology·Ursula TheuretzbacherGuy E Thwaites
Mar 14, 2019·Current Opinion in Pulmonary Medicine·Simon F K LeeMarc Lipman
Jul 5, 2019·International Journal of Molecular Sciences·Timothy W MouralClifford E Berkman
Nov 19, 2019·Progress in Biophysics and Molecular Biology·Ludovica Mascolo, Dirk Bald
Jan 8, 2021·ChemMedChem·Guilherme F S FernandesJean L Dos Santos
Dec 29, 2020·Antimicrobial Agents and Chemotherapy·Yunlong LiAnil K Ojha
Jul 18, 2020·ACS Medicinal Chemistry Letters·Elisa AzzaliMarco Pieroni
Apr 3, 2021·Frontiers in Cellular and Infection Microbiology·Hee-Jeong YangLaura E Via
Apr 5, 2021·Cellular Microbiology·Neeraja Subhash, Varadharajan Sundaramurthy
Apr 24, 2020·Journal of Natural Products·Changli SunJunying Ma
Apr 8, 2020·Journal of Medicinal Chemistry·Vadim MakarovSean Ekins

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antitubercular Agents

Antitubercular agents are pharmacologic agents for treatment of tuberculosis. Discover the latest research on antitubercular agents here.

Antitubercular Agents (ASM)

Antitubercular agents are pharmacologic agents for treatment of tuberculosis. Discover the latest research on antitubercular agents here.