The presubiculum is preserved from neurodegenerative changes in Alzheimer's disease

Acta Neuropathologica Communications
Christina E MurrayTammaryn Lashley

Abstract

In the majority of affected brain regions the pathological hallmarks of Alzheimer's disease (AD) are β-amyloid (Aβ) deposits in the form of diffuse and neuritic plaques, tau pathology in the form of neurofibrillary tangles, neuropil threads and plaque-associated abnormal neurites in combination with an inflammatory response. However, the anatomical area of the presubiculum, is characterised by the presence of a single large evenly distributed 'lake-like' Aβ deposit with minimal tau deposition or accumulation of inflammatory markers. Post-mortem brain samples from sporadic AD (SAD) and familial AD (FAD) and two hereditary cerebral amyloid diseases, familial British dementia (FBD) and familial Danish dementia (FDD) were used to compare the morphology of the extracellular proteins deposited in the presubiculum compared to the entorhinal cortex. The level of tau pathology and the extent of microglial activation were quantitated in the two brain regions in SAD and FAD. Frozen tissue was used to investigate the Aβ species and proteomic differences between the two regions. Consistent with our previous investigations of FBD and FDD cases we were able to establish that the 'lake-like' pre-amyloid deposits of the presubiculum were not a ...Continue Reading

References

Jul 1, 1991·Brain Pathology·A ProbstJ Ulrich
Jan 1, 1991·Acta Neuropathologica·H Braak, E Braak
Oct 1, 1989·Journal of Neuroimmunology·S ItagakiD Selkoe
Apr 19, 1986·Lancet·J M Bland, D J Altman
May 1, 1988·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·H J GundersenA Vesterby
Aug 5, 1998·Journal of Neuropathology and Experimental Neurology·H M WisniewskiJ Wegiel
Apr 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·R VidalB Frangione
Aug 22, 2000·Journal of Neuropathology and Experimental Neurology·D R ThalH Braak
Mar 16, 2002·Journal of Neuropathology and Experimental Neurology·Janice L HoltonTamas Revesz
Nov 28, 2002·Advanced Drug Delivery Reviews·Jorge Ghiso, Blas Frangione
Aug 3, 2004·The Journal of Biological Chemistry·Keiro ShirotaniHarald Steiner
Oct 12, 2004·Neurobiology of Disease·Sébastien S HébertBart De Strooper
May 17, 2005·Nature Neuroscience·Dimitrios DavalosWen-Biao Gan
Jun 22, 2005·Cellular and Molecular Life Sciences : CMLS·A RostagnoJ Ghiso
Jul 20, 2005·The Journal of Biological Chemistry·Angeliki FotinopoulouSpiros Efthimiopoulos
Nov 30, 2005·Methods : a Companion to Methods in Enzymology·Xiang H-F ZhangLawrence A Chasin
Oct 25, 2007·Cell·Dennis J Selkoe, Michael S Wolfe
Jul 25, 2008·The Journal of Biological Chemistry·Gopal Thinakaran, Edward H Koo
Aug 30, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shuji MatsudaLuciano D'Adamio
Mar 21, 2009·Nature Reviews. Neuroscience·N M van StrienM P Witter
Mar 24, 2009·Annual Review of Immunology·Richard M Ransohoff, V Hugh Perry
Apr 1, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hirokazu OkadaTae-Wan Kim
Jun 17, 2010·Journal of Neural Transmission·C Y Daniel Lee, Gary E Landreth
Jun 26, 2010·Frontiers in Human Neuroscience·Jean C AugustinackBruce Fischl
Apr 30, 2011·Physiological Reviews·Helmut KettenmannAlexei Verkhratsky
Jul 15, 2011·Brain : a Journal of Neurology·Tammaryn LashleyTamas Revesz

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Citations

Jun 13, 2020·Nanomedicine : Nanotechnology, Biology, and Medicine·Abhijith G KarkisavalRatnesh Lal

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Methods Mentioned

BETA
laser capture microdissection
protein assay

Software Mentioned

GraphPad Prism
Image J
Progenesis QI
Webgestalt
excel
GraphPad

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