The preterm infant with thrombosis

Archives of Disease in Childhood. Fetal and Neonatal Edition
Rukhmi Bhat, P Monagle

Abstract

In paediatrics, sick preterm infants are at highest risk of developing thrombotic complications. Haemostasis is in a fine balance in the neonatal period, despite age-related differences in coagulation proteins. However, both inherited and acquired risk factors can disrupt this balance and can lead to thrombosis. Important risk factors are sepsis, asphyxia, dehydration, central venous lines and inherited and acquired thrombophilia. Among various treatment modalities, anticoagulation is primarily used in the management of thrombosis. Different agents, dosages and durations of treatment in this age group are extrapolated from adult data. The article reviews the epidemiology, pathophysiology, risk factors, diagnosis and treatment of thrombotic disorders in preterm infants.

Citations

Nov 11, 2015·Seminars in Fetal & Neonatal Medicine·Revathi RajagopalPaul Monagle
Oct 12, 2013·The Journal of Pediatrics·Habib HaddadWalid El-Naggar
Nov 4, 2015·Early Human Development·Perrine DuppréSascha Meyer
Aug 4, 2015·Revista chilena de pediatría·Patricia Álvarez ZDiego Rodríguez V
Aug 20, 2016·Archives of Disease in Childhood·Revathi RajagopalPaul Monagle
Dec 3, 2016·Journal of Perinatology : Official Journal of the California Perinatal Association·J C BohnhoffM Good
Jul 28, 2020·Pediatric Blood & Cancer·Priscila Grizante-LopesJorge David Aivazoglou Carneiro
Aug 4, 2015·Journal of Pediatric Orthopedics. Part B·Senol BekmezNurullah Okumus
Aug 15, 2013·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Galit RashishUNKNOWN Thrombosis and Hemostasis in Newborns (THiN) Group

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