The pretreatment plasma level and diagnostic utility of M-CSF in benign breast tumor and breast cancer patients

Clinica Chimica Acta; International Journal of Clinical Chemistry
Sławomir ŁawickiMarek Wojtukiewicz

Abstract

In the present study, we investigated the plasma levels of M-CSF and commonly accepted tumor marker (antigen CA 15-3) in breast cancer patients in relation to the group with benign breast tumor and to the healthy controls. Additionally, we compared the plasma level of M-CSF with the tumor stage of breast cancer and defined the diagnostic criteria: sensitivity, specificity, the positive and the negative predictive values. Moreover, we defined the receiver-operating characteristics (ROC) curve for M-CSF and CA 15-3, and correlation between both parameters. M-CSF and CA 15-3 were measured in 80 patients with breast cancer, 17 patients with benign breast tumor and in 30 healthy subjects. M-CSF was determined using enzyme-linked immunosorbent assay (ELISA). CA 15-3 was measured using a microparticle enzyme immunoassay kit (MEIA). There were statistically significant differences in the levels of circulating M-CSF and CA 15-3 in the breast cancer patients comparing to the group with benign breast tumor and to the control group. The levels of M-CSF and CA 15-3 were also significantly higher in patients with more advanced tumor stage. Statistically significant positive correlation was observed between the M-CSF and CA 15-3 levels. The M...Continue Reading

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Citations

Oct 18, 2012·Bulletin of Mathematical Biology·Duan ChenAvner Friedman
Apr 16, 2010·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Martin DonachMaria O Nicoletto
Jan 4, 2008·Cancer Research·Rulla M TamimiSusan E Hankinson
Jul 8, 2010·Clinical Chemistry and Laboratory Medicine : CCLM·Marta Łukaszewicz-ZajacMaciej Szmitkowski
Mar 11, 2009·Frontiers in Bioscience (Landmark Edition)·Melissa HunterClay Marsh
Apr 2, 2013·Journal of Theoretical Biology·Kang-Ling LiaoAvner Friedman
Jul 6, 2012·Journal of Theoretical Biology·Barbara SzomolayAvner Friedman
Jul 28, 2018·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Monika ZajkowskaSławomir Ławicki
Aug 28, 2020·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Karen A AutioHeather L McArthur

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