Abstract
In the present study, we investigated the plasma levels of M-CSF and commonly accepted tumor marker (antigen CA 15-3) in breast cancer patients in relation to the group with benign breast tumor and to the healthy controls. Additionally, we compared the plasma level of M-CSF with the tumor stage of breast cancer and defined the diagnostic criteria: sensitivity, specificity, the positive and the negative predictive values. Moreover, we defined the receiver-operating characteristics (ROC) curve for M-CSF and CA 15-3, and correlation between both parameters. M-CSF and CA 15-3 were measured in 80 patients with breast cancer, 17 patients with benign breast tumor and in 30 healthy subjects. M-CSF was determined using enzyme-linked immunosorbent assay (ELISA). CA 15-3 was measured using a microparticle enzyme immunoassay kit (MEIA). There were statistically significant differences in the levels of circulating M-CSF and CA 15-3 in the breast cancer patients comparing to the group with benign breast tumor and to the control group. The levels of M-CSF and CA 15-3 were also significantly higher in patients with more advanced tumor stage. Statistically significant positive correlation was observed between the M-CSF and CA 15-3 levels. The M...Continue Reading
References
Feb 1, 1995·Annals of Medicine·B M Kacinski
Jan 1, 1996·Breast Cancer Research and Treatment·S M SchollF R Stanley
Jan 1, 1997·Molecular Reproduction and Development·B M Kacinski
Feb 18, 1998·The Prostate·D M SavareseT Savarese
Dec 11, 1999·Gynecologic and Obstetric Investigation·K ChaoH Ng
Jan 14, 2000·Breast Cancer Research and Treatment·S J HinesG W Krystal
Oct 6, 2000·Journal of Pain and Symptom Management·R J Dunlop, C W Campbell
Aug 2, 2001·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·A J Sasco
Aug 23, 2001·The Journal of Surgical Research·A T MancinoE Abe
Jun 5, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R KokkoM Hakama
Jul 13, 2002·International Journal of Cancer. Journal International Du Cancer·Piotr RutkowskiJan Steffen
Apr 15, 2004·Clinical Chemistry and Laboratory Medicine : CCLM·Barbara MroczkoGrazyna Jurkowska
Citations
Oct 18, 2012·Bulletin of Mathematical Biology·Duan ChenAvner Friedman
Apr 16, 2010·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Martin DonachMaria O Nicoletto
Dec 20, 2007·Nursing Research·Debra E LyonChristine Schubert
Jan 4, 2008·Cancer Research·Rulla M TamimiSusan E Hankinson
Jul 8, 2010·Clinical Chemistry and Laboratory Medicine : CCLM·Marta Łukaszewicz-ZajacMaciej Szmitkowski
Mar 11, 2009·Frontiers in Bioscience (Landmark Edition)·Melissa HunterClay Marsh
Sep 20, 2012·Growth Factors·Sławomir LawickiMaciej Szmitkowski
Oct 21, 2011·Growth Factors·Sławomir LawickiMaciej Szmitkowski
Jul 13, 2013·Advances in Medical Sciences·S ŁawickiM Szmitkowski
Apr 2, 2013·Journal of Theoretical Biology·Kang-Ling LiaoAvner Friedman
May 12, 2009·Experimental Cell Research·Kader Yagiz, Susan R Rittling
May 22, 2013·Growth Factors·Sławomir ŁawickiMaciej Szmitkowski
Jul 6, 2012·Journal of Theoretical Biology·Barbara SzomolayAvner Friedman
Feb 27, 2016·Annals of Laboratory Medicine·Sławomir ŁawickiMaciej Szmitkowski
Jul 28, 2018·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Monika ZajkowskaSławomir Ławicki
Mar 2, 2019·Pathology Oncology Research : POR·Emilia LubowickaSławomir Ławicki
Aug 28, 2020·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Karen A AutioHeather L McArthur