The prevalence and clinical implications of c-kit expression in plasma cell myeloma

Histopathology
G PruneriA Neri

Abstract

To evaluate the clinical implications of c-kit (CD117) expression in plasma cell myeloma (PCM). We first evaluated the reliability of immunohistochemistry in assessing c-kit expression by comparing the results with those obtained by flow cytometry and gene expression arrays in 22 PCM and in 10 PCM cell lines. Immunohistochemical results showed a perfect concordance with those of flow cytometry; likewise, immunohistochemical and gene expression data were also concordant in all but one PCM and cell lines analysed. Then, we investigated the clinical implications of c-kit immunoreactivity in bone marrow biopsies of 85 PCM patients with a mean follow-up of 41 months. C-kit immunoreactivity was detected in 24 (28.2%) of the 85 cases and it was significantly associated with a high microvessel density, but not with traditional clinicopathological characteristics or with survival. Our findings suggest that immunohistochemistry is a reliable indicator of c-kit gene expression and reinforce the notion that approximately one-third of PCM express high levels of c-kit. The lack of association with traditional clinicopathological parameters and patient survival suggests that c-kit expression may not be an adjunct in predicting the clinical co...Continue Reading

References

Apr 20, 1990·Cell·A Ullrich, J Schlessinger
Dec 1, 1994·British Journal of Haematology·R M LemoliS Tura
Dec 1, 1996·British Journal of Haematology·M OcqueteauJ F San Miguel
Sep 29, 2000·Experimental Hematology·F BertoliniG Pruneri
Mar 16, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael C HeinrichChristopher L Corless
May 7, 2002·Nature Reviews. Cancer·W Michael Kuehl, P Leif Bergsagel
Mar 21, 2003·American Journal of Clinical Pathology·Jason L Hornick, Christopher D M Fletcher
May 14, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Katia ScotlandiPiero Picci
May 22, 2003·Genes, Chromosomes & Cancer·Sonia FabrisAntonino Neri
Dec 17, 2003·Virchows Archiv : an International Journal of Pathology·A LugliS Dirnhofer

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Citations

Jul 14, 2005·Biomedical Research·Masahiko OhataMamoru Isemura
Jan 20, 2009·Leukemia & Lymphoma·Tanya M WildesRavi Vij
May 29, 2007·Leukemia Research·William C KisseberthThomas J Rosol
Oct 25, 2016·International Journal of Molecular Sciences·Philip EganH Denis Alexander
Apr 30, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gema MateoUNKNOWN GEM Study Group
Jun 14, 2017·Archives of Pathology & Laboratory Medicine·Huan-You Wang, Youli Zu

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