The prevalence and clinical significance of (18) F-2-fluoro-2-deoxy-D-glucose (FDG) uptake in the thyroid gland on PET or PET-CT in patients with lymphoma

Hematological Oncology
Michael LinSeu Som

Abstract

F(18) -2-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET) has become a well established tool in staging and assessing therapy response in lymphoma. Incidental thyroid uptake on PET is not uncommon and can pose a diagnostic and management challenge. We retrospectively evaluate the prevalence and clinical significance of incidental FDG uptake in the thyroid gland in patients with lymphoma. 1868 lymphoma patients underwent PET and PET-CT between August 2002 and August 2008. 52 patients (2.8%) demonstrated FDG thyroid uptake (M  =  17, F =  35; mean age 63 yr). Thyroid uptake was determined as focal or diffuse, maximum standardized uptake values (SUVmax) recorded as well as SUV max ratio compared to background mediastinum activity (SUVR). Corresponding CT findings on PET-CT were evaluated independently. Results were correlated with clinical, histopathological and imaging follow-up. 30 (1.6%) patients had focal thyroid uptake. 16 (53%) had histological confirmation either by surgery (n  =  7) or FNA under USS (n  =  9). The final diagnosis was benign in 12/30 patients and malignant in 9/30. The malignancy risk for focal thyroid uptake was 30%. Five patients had intercurrent thyroid cancer (four papillary, one microi...Continue Reading

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Citations

Feb 24, 2011·ANZ Journal of Surgery·Ivan Ho ShonPeter Campbell
Dec 31, 2011·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Michael Lin, Chaitanya Ambati
Jul 31, 2014·The Surgeon : Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·Sahar ElzeinSabapathy Prakash Balasubramanian
Feb 28, 2018·Hematological Oncology·Salvatrice MancusoSergio Siragusa
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Mar 18, 2019·BMJ Case Reports·Cristian Marco-AlacidCarlos Sánchez-Juan

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