The prevalence and incidence rate of pulmonary arterial hypertension in systemic sclerosis: Systematic review and meta-analysis

Autoimmunity Reviews
Manuel Rubio-RivasXavier Corbella

Abstract

The present study aimed to assess the prevalence and incidence rate of pulmonary arterial hypertension (PAH) in Systemic Sclerosis (SSc). The review was undertaken using MEDLINE and SCOPUS from June 1962 to May 2019 and the terms: ("Scleroderma, Systemic"[MesH]) AND "Hypertension, Pulmonary"[MesH]. The Newcastle-Ottawa Scale (NOS) was used for the qualifying assessment. The inverse variance-weighted method was performed. Twenty-four studies were included in the global PAH prevalence study. They comprised data from 9804 SSc patients. The overall PAH prevalence found was 6.4% (95%CI 5%-8.3%). Fourteen studies were included in the PAH prevalence study for lcSSc. They comprised data from 4987 lcSSc patients. The PAH prevalence found in lcSSc was 7.7% (95%CI 5.3%-11.1%). Twelve studies were included in the PAH prevalence study for dcSSc. They comprised data from 1790 dcSSc patients. The PAH prevalence found in dcSSc was 6.3% (95%CI 4.5%-8.9%). Fifteen studies showed PAH incidence of an entire SSc cohort. They comprised data from 5926 SSc patients. The overall PAH incidence found was 18.2 cases per 1000 person-years (95%CI 12-27.4). Eight studies showed PAH incidence for lcSSc. They comprised data from 2721 patients. The overall PAH ...Continue Reading

References

Jan 18, 1989·Journal of the National Cancer Institute·C B Begg, J A Berlin
Apr 1, 1986·Arthritis and Rheumatism·A M StupiT A Medsger
Oct 16, 2001·La Revue de médecine interne·D LaunayB Devulder
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Mar 3, 2007·Annals of the Rheumatic Diseases·Virginia D Steen, Thomas A Medsger
May 31, 2008·Annals of the Rheumatic Diseases·M C VonkP L A van Daele
Dec 8, 2009·QJM : Monthly Journal of the Association of Physicians·S I NihtyanovaC P Denton
Jun 16, 2010·Internal Medicine Journal·P HissariaP J Roberts-Thomson
Nov 23, 2011·Clinical Rheumatology·Pavel JansaAles Linhart
May 21, 2013·Annals of the Rheumatic Diseases·J Gerry CoghlanUNKNOWN DETECT study group
Jul 3, 2013·Clinical Rheumatology·Gemma StricklandNeil McHugh
Jun 17, 2014·Seminars in Arthritis and Rheumatism·Manuel Rubio-RivasVicent Fonollosa
Jul 15, 2015·Medicina clínica·Francisco José García HernándezJulio Sánchez Román
Mar 9, 2017·Arthritis Research & Therapy·Kathleen MorrisroeUNKNOWN Australian Scleroderma Interest Group (ASIG)
May 13, 2017·The European Respiratory Journal·Els VandecasteeleVanessa Smith
Nov 12, 2017·Seminars in Arthritis and Rheumatism·Beatriz E JovenPatricia E Carreira
Mar 23, 2018·The European Respiratory Journal·J Gerry CoghlanEkkehard Grünig
May 29, 2018·Clinical Rheumatology·Christopher A MecoliLaura K Hummers
Dec 12, 2018·Clinical Rheumatology·Francisco J García-HernándezUNKNOWN Spanish Society of Internal Medicine (SEMI)
Dec 14, 2018·The European Respiratory Journal·Gérald SimonneauRogerio Souza

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Citations

Jun 26, 2021·The European Respiratory Journal·David LaunayVincent Sobanski
Aug 20, 2021·European Respiratory Review : an Official Journal of the European Respiratory Society·Ashraful HaqueRobin Condliffe

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