The prevalence and spectrum of alpha and beta thalassaemia in Guangdong Province: implications for the future health burden and population screening

Journal of Clinical Pathology
X-M XuM Zhong

Abstract

Thalassaemia is a good candidate disease for control by preventive genetic programmes in developing countries. Accurate population frequency data are needed for planning the control of thalassaemia in the high risk Guangdong Province of southern China. In total, 13397 consecutive samples from five geographical areas of Guangdong Province were analysed for both haematological and molecular parameters. There was a high prevalence of carriers of alpha thalassaemia (8.53%), beta thalassaemia (2.54%), and both alpha and beta thalassaemia (0.26%). Overall, 11.07% of the population in this area were heterozygous carriers of alpha and beta thalassaemia. The mutation spectrum of alpha and beta thalassaemia and its constitution were fully described in this area. This study reports the true prevalence of silent alpha thalassaemia in the southern China population for the first time. In addition, two novel mutations that give rise to alpha thalassaemia, one deletion resulting in beta thalassaemia, and a rare deletion (--(THAI) allele) previously unreported in mainland China were detected. The frequency of the most common mutation, the Southeast Asian type of deletion (--(SEA), accounting for 48.54% of all alpha thalassaemias) was similar to...Continue Reading

References

Oct 1, 1988·British Journal of Haematology·N Fischel-GhodsianDouglas R Higgs
Oct 1, 1987·Journal of Medical Genetics·Y T Zeng, S Huang
Aug 1, 1993·Human Genetics·T M KoT Y Lee
Aug 1, 1996·Nature Medicine·D J Weatherall, J B Clegg
Mar 23, 1999·British Journal of Haematology·V ChanT K Chan
Aug 24, 2000·The New England Journal of Medicine·F E ChenV Chan
Jul 11, 2002·Obstetrics and Gynecology Clinics of North America·Antonio CaoRenzo Galanello
Oct 24, 2002·Blood·David H K ChuiV Chan

Citations

Aug 6, 2009·Annals of Hematology·Dong-Zhi LiRu Li
Apr 13, 2010·Annals of Hematology·Dong-Zhi LiJian Li
Oct 9, 2009·Journal of Assisted Reproduction and Genetics·Yanwen XuGuanglun Zhuang
Jun 15, 2011·Journal of Assisted Reproduction and Genetics·Xiaoting ShenTao Li
Nov 10, 2006·The British Journal of Nutrition·Zumin ShiGerd Holmboe-Ottesen
Jun 24, 2010·European Journal of Human Genetics : EJHG·Nicole E CousensMartin B Delatycki
Mar 11, 2005·Current Opinion in Obstetrics & Gynecology·Tse N LeungTony Kh Chung
Apr 8, 2006·Current Opinion in Obstetrics & Gynecology·Lin Wai ChanTony Kwok Hung Chung
May 28, 2010·BMC Genomics·Minghui WangZewei Luo
Jan 26, 2011·PloS One·Qiuying HuangQingge Li
May 9, 2007·Clinical Chemistry and Laboratory Medicine : CCLM·Helene PuehringerChristian Oberkanins
Apr 29, 2014·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Can LiaoDong-Zhi Li
Jul 15, 2015·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Li ZhenDong-Zhi Li
Nov 13, 2007·Hemoglobin·Can LiaoDong-Zhi Li
Nov 23, 2013·Hemoglobin·Jian-Pei FangSuqin Chen
Apr 19, 2013·Hemoglobin·Lu-Hong Xu, Jian-Pei Fang
Apr 23, 2013·Hemoglobin·Hoa Van NguyenFrank P Schelp
Dec 12, 2012·Hemoglobin·Na LiuDong-Zhi Li
Apr 18, 2009·Hemoglobin·Yu Yang, Dong-Zhi Li
Jan 17, 2012·Hemoglobin·Hai-Shen TangDong-Zhi Li
Mar 29, 2016·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Dong-Zhi LiYan-Mei Ou
Aug 21, 2015·Hematology·Jing HeBaosheng Zhu
Jan 15, 2013·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Can Liao, Dong-Zhi Li
Oct 26, 2011·Clinical Chemistry and Laboratory Medicine : CCLM·Ying-Na LiuDong-Zhi Li
Apr 21, 2009·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Can LiaoDong-Zhi Li
May 27, 2014·Blood Cells, Molecules & Diseases·Ji-Wu LouYanhui Liu
Jan 27, 2017·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Jing HeBaosheng Zhu
Jan 7, 2017·Blood·Duantida SongdejBHFS International Consortium
Mar 10, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Phudit JatavanTheera Tongsong
Jun 9, 2016·American Journal of Human Biology : the Official Journal of the Human Biology Council·Hongxian LiuZhaoqing Yang
Dec 27, 2005·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Dong-Zhi LiJia-Xue Wei
Mar 23, 2007·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Qiu-Ming LiD Li
Mar 1, 2017·International Journal of Laboratory Hematology·Y WangAihua Yin
Aug 5, 2017·Journal of Clinical Laboratory Analysis·Pingsen ZhaoWei Guo
May 27, 2014·International Journal of Molecular Sciences·Nur Fatihah Mohd YatimBadrul Hisham Yahaya
Jan 24, 2015·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Xinyan LiYili Zhao
Jan 8, 2019·Hemoglobin·Gui-Lan ChenDong-Zhi Li
Aug 16, 2006·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·D Li
Mar 16, 2007·Fetal Diagnosis and Therapy·Can LiaoDong-Zhi Li
May 4, 2018·Bioscience Reports·Minghuan SuoTing Hu
Jan 18, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Dong-Zhi Li, Hai-Shen Tang
Feb 12, 2008·Prenatal Diagnosis·Hua HuZhiqing Liang
Feb 13, 2008·American Journal of Hematology·Geoffrey T GibneyDavid H K Chui
Jul 23, 2008·Prenatal Diagnosis·Can LiaoDong-Zhi Li
Nov 30, 2005·American Journal of Hematology·Li ZesongZhang Wen
Dec 13, 2005·Annals of the New York Academy of Sciences·David H K Chui
Nov 19, 2010·Expert Review of Hematology·Roshan ColahAnita Nadkarni
Oct 15, 2010·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Jia-Xue WeiDong-Zhi Li
Apr 1, 2015·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Sevcan Tug BozdoganTomasz Gambin
Sep 12, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Wenqian CaiXijiang Hu
Feb 9, 2007·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·Can LiaoD-Z Li
Oct 28, 2019·Journal of Clinical Pathology·Jianlong ZhuangShuhong Zeng
May 5, 2020·BJOG : an International Journal of Obstetrics and Gynaecology·Weigang LvLingqian Wu
Jul 29, 2020·Hematology·Shiqiang LuoNing Tang
Jun 27, 2020·Hemoglobin·Reza AlibakhshiLeila Omidniakan
Mar 12, 2011·Pediatric Blood & Cancer·Xiao-Lin YinXinhua Zhang
Apr 1, 2015·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Xing-Mei XieDong-Zhi Li
May 9, 2015·International Journal of Laboratory Hematology·M-Y WuD-Z Li
Jul 17, 2015·International Journal of Laboratory Hematology·W-J CaiD-Z Li
Sep 28, 2016·Intractable & Rare Diseases Research·David S Cram, Daixing Zhou
May 26, 2017·Tropical Medicine & International Health : TM & IH·Yuzhen LiangYongrong Lai
Jul 15, 2018·International Journal of Hematology·Kesara Nittayaboon, Chamnong Nopparatana
Dec 17, 2019·Scandinavian Journal of Clinical and Laboratory Investigation·Youqiong LiXin Wu
Aug 28, 2020·Pediatric Investigation·Xiaoxiao Xu, Xuedong Wu
Jan 22, 2005·Hemoglobin·Anne GilbertWendy N Erber
Aug 19, 2018·BMC Medical Genetics·Liangying ZhongMin Liu
Aug 10, 2020·Journal of Clinical Laboratory Analysis·Youqiong LiMenghui Meng
Nov 19, 2010·Pediatric Hematology and Oncology·Dong-Zhi Li
May 29, 2009·Prenatal Diagnosis·Dong-Zhi Li
Jul 29, 2016·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Yong ZouJun-Jie Bao
Jan 8, 2020·BMC Medical Genetics·Yaowu ZhuYanjun Lu
Mar 30, 2019·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Dong-Zhi Li, Yan-Dong Yang
Mar 16, 2011·The Tohoku Journal of Experimental Medicine·Zhanhui OuXiaofang Sun
Jan 7, 2021·International Journal of Laboratory Hematology·Jialong XuYinge Wu
Jan 22, 2021·International Archives of Occupational and Environmental Health·Hongwu WangLian Ma

Related Concepts

Genetic Screening Method
Globin
Genetic Carriers
Antenatal Screening Procedures
Neonatal Screening
Alpha-Thalassemia
Thalassemia Minor
Educational Needs Assessment

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.