The Prevalence, Genotype and Antimicrobial Susceptibility of High- and Low-Level Mupirocin Resistant Methicillin-Resistant Staphylococcus aureus.

Annals of Dermatology
Se Young ParkSeok Don Park

Abstract

Mupirocin has been used for the treatment of skin infections and eradication of nasal carriage of methicillin-resistant Staphylococcus aureus (MRSA). The increased use of this antibiotic has been accompanied by outbreaks of MRSA that are resistant to mupirocin. This study aims to determine the prevalence, genotype and antimicrobial susceptibility of mupirocin-resistant MRSA from 4 Korean hospitals. A total 193 MRSA clinical isolates were collected from four university hospitals. Antimicrobial susceptibility tests, including mupirocin, and pulsed-field gel electrophoresis (PFGE) pattern analysis were performed. Overall, 27 of the 193 (14.1%) MRSA isolates were resistant to mupirocin. All of the (A) hospital isolates showed high-level (HL) mupirocin resistance and the low-level (LL) mupirocin resistant strains were from three other hospitals. The PFGE patterns of 16 mupirocin-resistant isolates were divided into 5 clusters (1-5), and the nine HL mupirocin-resistant isolates belonged to cluster 1. Both the HL and LL mupirocin-resistant MRSA isolates were susceptible to vancomycin and rifampin, but they were resistant to ciprofloxacin, clindamycin and tetracycline. The erythromycin and fusidic acid resistance rates were different b...Continue Reading

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Citations

Nov 2, 2012·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·F LayerW Witte
Oct 1, 2014·Applied Microbiology and Biotechnology·Sung-Hwan EomYoung-Mog Kim
Dec 12, 2012·Enfermedades infecciosas y microbiología clínica·Jesús Molina-CabrillanaAntonio M Martín-Sánchez
Mar 14, 2014·Journal of Chemotherapy·Maria Fernanda B PereiraMarcelo J Mimica
Jun 6, 2017·Chemical Biology & Drug Design·Siew Mei Samantha NgC S Brian Chia
Apr 1, 2015·Antimicrobial Agents and Chemotherapy·Nina K AntonovChristine T Lauren
Aug 14, 2018·Chemical Biology & Drug Design·Giovinna ArfanCheng San Brian Chia
Dec 6, 2017·Asian Pacific Journal of Tropical Medicine·Ebru Şebnem Yılmaz, Özkan Aslantaş
Aug 24, 2019·Journal of Global Antimicrobial Resistance·Masoud DadashiMehdi Goudarzi
Dec 16, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Saeed KhoshnoodMahtab Abdi
Aug 4, 2021·Journal of the American Chemical Society·Rachel A JohnsonBo Li

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Methods Mentioned

BETA
PCR
electrophoresis
genotyping

Software Mentioned

GelCompar II

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