Abstract
Mupirocin has been used for the treatment of skin infections and eradication of nasal carriage of methicillin-resistant Staphylococcus aureus (MRSA). The increased use of this antibiotic has been accompanied by outbreaks of MRSA that are resistant to mupirocin. This study aims to determine the prevalence, genotype and antimicrobial susceptibility of mupirocin-resistant MRSA from 4 Korean hospitals. A total 193 MRSA clinical isolates were collected from four university hospitals. Antimicrobial susceptibility tests, including mupirocin, and pulsed-field gel electrophoresis (PFGE) pattern analysis were performed. Overall, 27 of the 193 (14.1%) MRSA isolates were resistant to mupirocin. All of the (A) hospital isolates showed high-level (HL) mupirocin resistance and the low-level (LL) mupirocin resistant strains were from three other hospitals. The PFGE patterns of 16 mupirocin-resistant isolates were divided into 5 clusters (1-5), and the nine HL mupirocin-resistant isolates belonged to cluster 1. Both the HL and LL mupirocin-resistant MRSA isolates were susceptible to vancomycin and rifampin, but they were resistant to ciprofloxacin, clindamycin and tetracycline. The erythromycin and fusidic acid resistance rates were different b...Continue Reading
References
Jun 1, 1992·The Journal of Antimicrobial Chemotherapy·P A MapleW Brumfitt
Aug 31, 1991·Lancet·R Wise, J Johnson
Apr 1, 1985·Antimicrobial Agents and Chemotherapy·R SutherlandA R White
Sep 19, 1994·The Medical Journal of Australia·T V RileyW B Grubb
Sep 1, 1993·Antimicrobial Agents and Chemotherapy·D A JanssenC A Kauffman
Dec 1, 1993·Kansenshōgaku zasshi. The Journal of the Japanese Association for Infectious Diseases·T Yokoyama
Oct 1, 1996·International Journal of Systematic Bacteriology·M HeyndrickxR C Berkeley
Dec 1, 1996·Antimicrobial Agents and Chemotherapy·M A RamseyT M Morton
Mar 25, 1998·The Journal of Antimicrobial Chemotherapy·B D Cookson
Apr 23, 1999·Journal of Applied Microbiology·D G ThomasA D Russell
Aug 12, 1999·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M C BastosM Giambiagi-deMarval
Aug 21, 2001·Journal of Korean Medical Science·H J LeeK P Schaal
Feb 13, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Miguel Pérez-FontánFrancisco Valdés
Mar 5, 2003·The Journal of Antimicrobial Chemotherapy·Hee-Jeong YunSunghoon Kim
Apr 19, 2003·Journal of Clinical Microbiology·Stephen MurchanBarry Cookson
Feb 10, 2004·Journal of Clinical Microbiology·Fernando ChavesJoaquín R Otero
Dec 27, 2005·Antimicrobial Agents and Chemotherapy·Jae Il YooYeong Seon Lee
Oct 18, 2006·Journal of Korean Medical Science·Jin Ah YangMin Ja Kim
Aug 29, 2007·Antimicrobial Agents and Chemotherapy·Andrew E SimorUNKNOWN Canadian Nosocomial Infection Surveillance Program
Citations
Nov 2, 2012·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·F LayerW Witte
Oct 1, 2014·Applied Microbiology and Biotechnology·Sung-Hwan EomYoung-Mog Kim
Feb 20, 2016·International Journal of Dermatology·Yoo Sang BaekHae Jun Song
Dec 12, 2012·Enfermedades infecciosas y microbiología clínica·Jesús Molina-CabrillanaAntonio M Martín-Sánchez
Sep 18, 2015·The Journal of Antimicrobial Chemotherapy·Carole NagantOlivier Denis
Mar 14, 2014·Journal of Chemotherapy·Maria Fernanda B PereiraMarcelo J Mimica
Jun 6, 2017·Chemical Biology & Drug Design·Siew Mei Samantha NgC S Brian Chia
Apr 1, 2015·Antimicrobial Agents and Chemotherapy·Nina K AntonovChristine T Lauren
Apr 27, 2016·Antimicrobial Agents and Chemotherapy·Elisabeth M HaismaPeter H Nibbering
Aug 5, 2016·Annals of Dermatology·Jung-Min ParkByung-Soo Kim
Aug 15, 2015·Annals of Dermatology·Mi-Young JungJun-Mo Yang
Oct 30, 2015·Annals of Dermatology·Sang Hyun ParkKun Park
Aug 14, 2018·Chemical Biology & Drug Design·Giovinna ArfanCheng San Brian Chia
Feb 21, 2018·Journal of Medical Microbiology·Sandhya NairUmender Sharma
Aug 4, 2018·Journal of Medical Microbiology·Dan TakeuchiShigeyuki Hamada
Jan 25, 2018·Veterinary Dermatology·Ji-Hyung ParkCheol-Yong Hwang
Aug 2, 2018·Annals of Dermatology·Woosung HongYoung Suck Ro
Dec 6, 2017·Asian Pacific Journal of Tropical Medicine·Ebru Şebnem Yılmaz, Özkan Aslantaş
Aug 24, 2019·Journal of Global Antimicrobial Resistance·Masoud DadashiMehdi Goudarzi
Dec 16, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Saeed KhoshnoodMahtab Abdi
Aug 4, 2021·Journal of the American Chemical Society·Rachel A JohnsonBo Li
Nov 23, 2021·Acta Microbiologica Et Immunologica Hungarica·Mehdi GoudarziMirmohammad Miri