PMID: 9421264Jan 8, 1998Paper

The prevalence of a YY synaptonemal complex over XY synapsis in an XYY man with exclusive XYY spermatocytes

Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology
A J Solari, G Rey Valzacchi

Abstract

An infertile XYY man was studied by synaptonemal complex analysis of microspread spermatocytes and by quantitation of germ cells in semithin sections. All the 74 spermatocytes micrographed have an XYY constitution, and the biopsy shows a homogeneous arrest of spermatogenesis at the spermatocyte/young spermatid stages. The overwhelming majority (86%) of spermatocytes showed a Y-Y bivalent plus a univalent X. The Y-Y bivalent is totally synapsed in 48% of the cells. In the remaining cells, the YY bivalent has an average synaptic segment covering 43% of its length that always includes Yp. Another 9% of the spermatocytes showed an XYY trivalent and 4% of the spermatocytes showed univalence of the three gonosomes. Progression through all the pachytene substages was observed in cells with the two main synaptic configurations, but a high level of germ cell death was observed at or immediately after the meiotic divisions. The prevalence of Y-Y synapsis arises from the longer homologous region and the higher speed of pairing between the two Y chromosomes. Germ cell death is probably related to the univalence of the X chromosome. Synaptic competition between three gonosomes seems to be similar to that found in triploid birds but is somew...Continue Reading

Citations

Sep 1, 2009·Expert Opinion on Medical Diagnostics·Liborio StuppiaGiandomenico Palka
Jul 19, 2017·Human Fertility : Journal of the British Fertility Society·Parnaz Borjian BoroujeniAnahita Mohseni Meybodi
Jul 26, 2011·Asian Journal of Andrology·Godfried W van der HeijdenWilly M Baarends
Sep 1, 2005·International Journal of Andrology·Nathalie RivesBertrand Macé
Aug 5, 2003·Nature Reviews. Genetics·Mark A Jobling, Chris Tyler-Smith
Feb 23, 2012·PloS One·Marieke de VriesPeter de Boer
Jan 30, 2015·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Liu WangQinghua Shi
Aug 13, 1999·Archives of Andrology·F MorelJ L Bresson
Sep 18, 2013·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Roberta B SciuranoAlberto J Solari
May 2, 2006·Current Opinion in Genetics & Development·Heather HallTerry Hassold

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