The prevalence of autoantibodies in complex regional pain syndrome type I

Mediators of Inflammation
Maaike DirckxFrank J P M Huygen

Abstract

Autoimmunity has been suggested as one of the pathophysiologic mechanisms that may underlie complex regional pain syndrome (CRPS). Screening for antinuclear antibodies (ANA) is one of the diagnostic tests, which is usually performed if a person is suspected to have a systemic autoimmune disease. Antineuronal antibodies are autoantibodies directed against antigens in the central and/or peripheral nervous system. The aim of this study was to compare the prevalence of these antibodies in CRPS patients with the normal values of those antibodies in the healthy population. Twenty seven (33%) of the 82 CRPS patients of whom serum was available showed a positive ANA test. This prevalence is significantly higher than in the general population. Six patients (7.3%) showed a positive result for typical antineuronal antibodies. This proportion, however, does not deviate from that in the general population. Our findings suggest that autoantibodies may be associated with the pathophysiology of CRPS, at least in a subset of patients. Further research is needed into defining this subset and into the role of autoantibodies in the pathogenesis of CRPS.

References

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Apr 5, 2002·Mediators of Inflammation·Frank J P M HuygenFreek J Zijlstra
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Oct 18, 2011·The Clinical Journal of Pain·Maaike DirckxFrank J P M Huygen
Jun 20, 2012·Nature Reviews. Neurology·Eric Lancaster, Josep Dalmau
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Citations

Jul 23, 2016·Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur·Rita KatznelsonHance Clarke
Dec 20, 2018·Journal of Breath Research·E J BijlF J P M Huygen
Oct 3, 2017·Rheumatology·Ramin RaoofNiels Eijkelkamp
Jul 12, 2017·Pain Practice : the Official Journal of World Institute of Pain·Pelle B PetersenMichael R Krogsgaard
Jun 22, 2017·Mediators of Inflammation·Krishna D BharwaniFrank J P M Huygen
Oct 25, 2017·Neuromodulation : Journal of the International Neuromodulation Society·Nadia KriekFrank J P M Huygen
Jan 11, 2020·Frontiers in Neurology·Takayuki FujiiJun-Ichi Kira
Aug 1, 2019·Molecular Diagnosis & Therapy·Krishna D BharwaniFrank J P M Huygen

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Methods Mentioned

BETA
fluorescence microscopy
PCA

Related Concepts

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Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

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