The prevalence of computed tomography-defined leaflet thrombosis in intra- versus supra-annular transcatheter aortic valve prostheses

Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions
Hashrul N RashidAdam J Brown

Abstract

Leaflet thrombosis (LT) defined by computed tomography (CT) following transcatheter aortic valve replacement (TAVR) has been shown to increase cerebrovascular events. The neo-sinus plays an important role in the development of LT. Intra-annular valves (IAV) have a larger neo-sinus when compared to supra-annular valves (SAV), and has been associated with larger thrombus burden. The prevalence of LT with IAV and SAV in a larger, diverse cohort is unknown. We performed a systematic review to assess the prevalence of LT in IAV versus SAV TAVR prostheses. Inclusion criteria were (1) reported CT-defined LT following TAVR, (2) comparison between LT and non-LT cohort, (3) separate registry/database, and (4) fully published status. A total of 2,013 citations were reviewed and 7 studies were included. Overall, 1,644 patients were included from 7 observational studies and the prevalence of LT following TAVR was 12.8%. The Portico valve system (IAV) had the highest prevalence of LT with 35.2%, followed by Symetis Acurate Neo (SAV) at 15.4% and the Lotus valve system (IAV) at 14.5%. LT occurred more frequently in IAV than SAV (13.5% vs. 7%, P = 0.02). Subanalysis of IAV versus SAV with the exclusion of the Portico valve was performed to ens...Continue Reading

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Citations

Jul 18, 2019·Annals of Biomedical Engineering·Immanuel David Madukauwa-DavidAjit P Yoganathan
Dec 4, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Ali R WahadatRicardo P J Budde
Apr 14, 2020·Current Pharmaceutical Design·M DrakopoulouΚ Toutouzas
Oct 25, 2020·Annals of Biomedical Engineering·Beatrice NchoAjit Yoganathan
Feb 20, 2021·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Raúl MorenoHolger Thiele
Jul 2, 2021·Current Cardiology Reports·Nina C WunderlichRobert J Siegel
Nov 12, 2021·Current Cardiology Reports·Makoto Nakashima, Hasan Jilaihawi

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