Apr 24, 2001

The prevalence of extraintestinal diseases in inflammatory bowel disease: a population-based study

The American Journal of Gastroenterology
Charles N BernsteinN Yu

Abstract

The aim of this study was to determine the prevalence of the major extraintestinal manifestations of inflammatory bowel disease (IBD) and their relation to disease diagnosis and gender. We used the population-based University of Manitoba IBD Database, which includes longitudinal files on all subjects of all health system contacts identified by International Classification of Diseases, 9th Revision, Clinical Modification codes for visit diagnosis. We extracted a cohort from our database, which included subjects with a known diagnosis of IBD for at least 10 yr. We then determined how many contacts each subject had for each of the following extraintestinal IBD-associated immune diseases: primary sclerosing cholangitis, ankylosing spondylitis, iritis/uveitis, pyoderma gangrenosum, and erythema nodosum. We calculated the prevalence of the extraintestinal diseases using an administrative definition of having at least five health system contacts for the diagnosis in question. This administrative definition has previously been validated in Crohn's disease and ulcerative colitis (UC). A total of 6.2% of patients with IBD had one of six major extraintestinal diseases studied in this report. Only 0.3% of patients had multiple extraintesti...Continue Reading

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  • Citations186

Citations

Mentioned in this Paper

Pathogenic Aspects
Primary Sclerosing Cholangitis
Pathogenesis
Immune System Diseases
Uveal Diseases
Colitis
Inflammatory Bowel Diseases
Pyoderma Gangrenosum
Intestinal Diseases
Ankylosing Spondylitis

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