The prevalence of glucose metabolism abnormalities in Greek women with polycystic ovary syndrome

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
Eftihios TrakakisDimitrios Kassanos

Abstract

The prevalence of glucose metabolism abnormalities in PCOS women worldwide varies between 10 and 40% but there are no data in Greek PCOS women. In this retrospective study the prevalence of glucose abnormalities and the indices of insulin resistance (IR) and whole-body insulin sensitivity were estimated in a Greek population with PCOS. Impaired glucose tolerance (IGT), impaired fasting glucose (IFG) and type 2 diabetes mellitus (t2DM) were calculated. The prevalence of IGT, IFG and t2DM in our PCOS population was 7.6, 5.1 and 1.7%, respectively. The total prevalence of glucose abnormalities was estimated as 14.1%. The prevalence of t2DM was three- to four-fold higher than in the general Greek female population of the same age as this was estimated by 2, recently published studies. PCOS women with increased BMI and waist circumference and age greater than 30 years, present more severe IR and decreased whole-body insulin sensitivity. Our data indicates a relatively high prevalence of glucose intolerance and t2DM in a Greek population with PCOS. Obese women with PCOS are in higher risk to develop glucose abnormalities and probably t2DM later in life and therefore every woman diagnosed with PCOS should undergo a 2-h post load OGTT.

References

Jul 21, 2000·The Journal of Clinical Endocrinology and Metabolism·A KatzM J Quon
Jul 21, 2000·The Journal of Clinical Endocrinology and Metabolism·M AsunciónH F Escobar-Morreale
Jul 7, 2001·American Journal of Physiology. Endocrinology and Metabolism·A DunaifE Diamanti-Kandarakis
Oct 31, 2001·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·S WeerakietA Rojanasakul
Nov 17, 2001·Journal of Diabetes and Its Complications·N Abate, M Chandalia
May 11, 2006·Human Reproduction·Xiaoli ChenLiangan Wang
Sep 19, 2007·The Medical Journal of Australia·Preeti DabadghaoRobert J Norman
Dec 7, 2007·The Journal of Clinical Endocrinology and Metabolism·Kelsey E S SalleyJohn E Nestler
Oct 2, 2008·Vascular Health and Risk Management·Demosthenes B PanagiotakosChristodoulos Stefanadis
Apr 7, 2009·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Juan J Espinós-GómezJoaquim Calaf
Apr 25, 2009·Diabetic Medicine : a Journal of the British Diabetic Association·N TentolourisP P Sfikakis

❮ Previous
Next ❯

Citations

Oct 10, 2013·Journal of Endocrinological Investigation·R Pasquali, A Gambineri
Dec 3, 2015·Current Obesity Reports·Thomas S Paterakis, Evanthia Diamanti-Kandarakis
Feb 11, 2016·European Journal of Clinical Nutrition·E PapakonstantinouG Dimitriadis
Nov 8, 2014·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·G BasiosE Hatziagelaki
Jan 29, 2013·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Ercan YilmazEngin Yildirim

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.