The prevalence of human papillomavirus infection in Iranian patients with sinonasal inverted papilloma

Journal of the Chinese Medical Association : JCMA
Somayeh JalilvandRasool Hamkar

Abstract

Inverted papilloma (IP) is an uncommon disease which arises in the mucosal membrane of the nasal cavity and paranasal sinus. It has been proposed that human papillomavirus (HPV) is the causal agent in the pathogenesis of IP and plays a key role in the progression from benign IP to malignancy. As there are no prior studies that focus on an Iranian population, this study intended to characterize the prevalence of HPV types in benign and malignant forms of IP. In this retrospective study, we included a total of 40 IP patients [37 benign IP and 3 IP/squamous cell carcinoma (SCC)] who were referred to Amiralam Hospital in Tehran from 2004-2006. HPV was detected in 18.9% and 100% of IP and IP/SCC cases, respectively. In all HPV positive cases of IP and IP/SCC cases, HPV6/11 and HPV16/18 were detected, respectively. Therefore, HPV types were different between the IP and IP/SCC patients, and this difference was statistically significant (p = 0.002). This study suggests that HPV6 and 11 may be involved in the development of IP, but HPV16 and 18 likely play an important role in the progression from benign to malignant form of IP.

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Citations

Aug 9, 2017·Journal of Medical Virology·Nasrin HeydariSomayeh Jalilvand
May 2, 2020·Journal of Otolaryngology - Head & Neck Surgery = Le Journal D'oto-rhino-laryngologie Et De Chirurgie Cervico-faciale·Cai LongAndrew Thamboo
Sep 1, 2017·International Forum of Allergy & Rhinology·Suat KılıçJean Anderson Eloy
Oct 14, 2020·Reviews in Medical Virology·Rohit GuptaStephen K Tyring
May 7, 2021·International Forum of Allergy & Rhinology·Wesley H SteppBrian D Thorp

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