The prevalence of immunologic injury in renal allograft recipients with de novo proteinuria.

PloS One
Qiquan SunZhihong Liu

Abstract

Post-transplant proteinuria is a common complication after renal transplantation; it is associated with reduced graft and recipient survival. However, the prevalence of histological causes has been reported with considerable variation. A clinico-pathological re-evaluation of post-transplant proteinuria is necessary, especially after dismissal of the term "chronic allograft nephropathy," which had been considered to be an important cause of proteinuria. Moreover, urinary protein can promote interstitial inflammation in native kidney, whether this occurs in renal allograft remains unknown. Factors that affect the graft outcome in patients with proteinuria also remain unclear. Here we collected 98 cases of renal allograft recipients who developed proteinuria after transplant, histological features were characterized using Banff scoring system. Cox proportional hazard regression models were used for graft survival predictors. We found that transplant glomerulopathy was the leading (40.8%) cause of post-transplant proteinuria. Immunological causes, including transplant glomerulopathy, acute rejection, and chronic rejection accounted for the majority of all pathological causes of proteinuria. Nevertheless, almost all patients that de...Continue Reading

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Citations

Sep 4, 2015·Transplantation·Anne Tsampalieros, Greg A Knoll
Sep 4, 2015·PloS One·Joshua M ThurmanHoward Trachtman
Mar 24, 2017·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Andriy V TrailinOlexander S Nikonenko
Apr 30, 2021·Néphrologie & thérapeutique·Elisabet Van Loon, Maarten Naesens
Jul 23, 2021·Clinical Transplantation·Sandesh ParajuliDidier Mandelbrot

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Methods Mentioned

BETA
biopsies
biopsy
electron microscopy

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