The prevalence of intestinal metaplasia in patients with and without peptic strictures

The American Journal of Gastroenterology
S L KimJ P Waring

Abstract

Several studies suggest that patients with esophageal peptic strictures have a high prevalence of Barrett's esophagus. However, these studies did not include appropriate control groups, were retrospective in nature, or did not strictly define Barrett's esophagus. Our aim was to compare the prevalence of Barrett's esophagus in patients with and without gastroesophageal reflux disease strictures in a prospective study. Seventy-nine patients referred for endoscopy for gastroesophageal reflux disease symptoms were evaluated. We collected demographic information and an esophageal symptom assessment. Biopsy specimens were obtained from peptic strictures, Schatzki rings, or from any areas of columnar-lined esophagus or mucosal injury. Barrett's esophagus was strictly defined as the presence of intestinal metaplasia from tubular esophagus. There were 46 patients without strictures and 28 patients with peptic strictures. Five patients had Schatzki's rings. The prevalence of intestinal metaplasia was 23.9% in patients without strictures, and 25% in patients with peptic strictures (p = NS). There was no difference in prevalence of short- or long-segment Barrett's esophagus between the groups. Patients with strictures were older than patie...Continue Reading

References

Feb 1, 1988·The Annals of Thoracic Surgery·A G LittleD B Skinner
Sep 1, 1983·Digestive Diseases and Sciences·S J SpechlerE M Schimmel
Feb 1, 1996·Gastroenterology·S J Spechler, R K Goyal

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Citations

Jan 13, 2000·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·S J WalkerN Birbeck
Jun 24, 2004·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·Sergio Angel MazzadiJuan Carlos Chiocca
May 23, 2002·Gastroenterology·Gary W Falk

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