The prevalence of non-classic adrenal hyperplasia due to 11 beta-hydroxylase deficiency among hirsute women in a Turkish population

Clinical Endocrinology
Fahrettin KeleştimurA Tutuş

Abstract

The present study was designed to determine the prevalence of 11 beta-hydroxylase deficiency in adult women with hirsutism in a Turkish population. One hundred and twenty-four consecutive unselected hirsute patients were studied. An ACTH stimulation test was performed in the midfollicular phase of the cycle on the patients and 20 age-matched controls by administration of a single bolus of 0.25 mg ACTH (1-24) at 0900 h. Serum 11-deoxycortisol levels were measured before, 30 and 60 minutes after ACTH injection. Basal free testosterone (fT), SHBG, cortisol and androstenedione (A) were also measured. The diagnosis of 11 beta-hydroxylase deficiency has been presumed when the serum 11-deoxycortisol response to ACTH stimulation exceeded three times the 95th percentile of controls. Basal hormone levels including fT and A were significantly higher in the hirsute women than in the healthy women. SHBG was significantly lower in the hirsute patients. Basal and ACTH stimulated 11-deoxycortisol levels were found to be significantly increased in the patients compared with the controls. Eight patients (6.5%) had an 11-deoxycortisol response higher than three times the upper normal limit. Using stringent diagnostic criteria, we have found that ...Continue Reading

Citations

Dec 12, 2012·European Journal of Endocrinology·Z KaracaF Kelestimur
Nov 1, 2005·Women's Health·Kursad UnluhizarciFahrettin Kelestimur
May 21, 2004·Reproductive Biomedicine Online·Yilmaz Sahin, Fahrettin Kelestimur
Jun 30, 2004·Trends in Endocrinology and Metabolism : TEM·Gregory A KaltsasAshley B Grossman
Feb 28, 2019·Journal of Endocrinological Investigation·S PolatF Kelestimur
Jan 11, 2020·Hormone Molecular Biology and Clinical Investigation·Sebastião Freitas de MedeirosMárcia Marly Winck Yamamoto
Dec 19, 2001·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·A G OzgenC Yilmaz
Feb 25, 2019·Reviews in Endocrine & Metabolic Disorders·Márcia Marly Winck Yamamoto, Sebastião Freitas de Medeiros
Jun 1, 2011·European Journal of Clinical Investigation·Kursad UnluhizarciFahrettin Kelestimur

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