The Prevalence of Orthostatic Hypotension: A Systematic Review and Meta-Analysis

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Nor I'zzati SaedonJames Frith

Abstract

Orthostatic hypotension (OH) is associated with increased risk of falls, cognitive impairment and death, as well as a reduced quality of life. Although it is presumed to be common in older people, estimates of its prevalence vary widely. This study aims to address this by pooling the results of epidemiological studies. MEDLINE, EMBASE, PubMed, Web of Science, and ProQuest were searched. Studies were included if participants were more than 60 years, were set within the community or within long-term care and diagnosis was based on a postural drop in systolic blood pressure (BP) ≥20 mmHg or diastolic BP ≥10 mmHg. Data were extracted independently by two reviewers. Random and quality effects models were used for pooled analysis. Of 23,090 identified records, 20 studies were included for community-dwelling older people (n = 24,967) and six were included for older people in long-term settings (n = 2,694). There was substantial variation in methods used to identify OH with differing supine rest duration, frequency and timing of standing BP, measurement device, use of standing and tilt-tables and interpretation of the diagnostic drop in BP. The pooled prevalence of OH in community-dwelling older people was 22.2% (95% CI = 17, 28) and 2...Continue Reading

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Citations

Feb 20, 2020·The New England Journal of Medicine·David A Ganz, Nancy K Latham
Nov 7, 2019·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Nor Izzati SaedonUNKNOWN L. MacKenzie
Sep 24, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·Lisanne J DommershuijsenM Kamran Ikram
Apr 1, 2020·Journal of the American Heart Association·Maw Pin Tan
Aug 5, 2020·Journal of Cardiovascular Translational Research·Anzhela SolovevaMarat Fudim
Nov 1, 2020·Drug and Therapeutics Bulletin·Jake Ryan Gibbon, James Frith
Jan 19, 2021·The Journal of Clinical Hypertension·Steven G Chrysant
Apr 25, 2021·BMJ : British Medical Journal·Artaza GilaniS Goya Wannamethee
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May 4, 2021·The American Journal of Medicine·Vishal N RaoJaved Butler
Jun 19, 2021·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Jake Ryan Gibbon, James Frith
Aug 14, 2021·Journal of the American Medical Directors Association·Ulla Hohtari-KivimäkiSirkka-Liisa Kivelä
Sep 4, 2021·Journal of the American Medical Directors Association·Elena M ChristopoulosAndrea B Maier

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