The prevalence of programmed death ligand-1 (PD-L1) expression in non-small cell lung cancer in an unselected, consecutive population

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Birgit Guldhammer SkovTorsten Skov

Abstract

Little is known about prevalence of PD-L1 expression in tumor cells of unselected patients with all stages of non-small cell lung cancer. The objective of this study is to assess the prevalence of PD-L1 positivity in patients with non-small cell lung cancer, to analyze the association between PD-L1 positivity and patients' clinicopathological characteristics, and to assess the use of immune-oncologic treatment in eligible patients. All non-small cell lung cancer patients diagnosed in a 10-month period in an unselected population of 1.7 million Caucasian inhabitants were evaluated with the PD-L1 IHC 22C3 pharmDx kit. A total of 819 patients were diagnosed with non-small cell lung cancer. Samples analyzable for PD-L1 expression were obtained from 97% of patients. In a multivariate analysis with cut-off at tumor proportion score ≥50%, lower stage was associated with lower prevalence of PD-L1 positivity with an odds ratio of 0.31 for stage I vs. stage IV. A significant difference in PD-L1 expression between squamous-cell carcinoma and adenocarcinoma was observed with odds ratio for adenocarcinoma 1.8. With cut-off tumor proportion score ≥1%, attenuated effects of the same direction were seen. For neither cut-off did type and locati...Continue Reading

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Citations

Feb 8, 2020·Journal of Pathology and Translational Medicine·Ji Hye KimHye Jeong Choi
Nov 3, 2020·Medical Oncology·Danielle Benedict SacdalanDennis L Sacdalan
Mar 11, 2021·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Fabien ForestMichel Péoc'h
Mar 11, 2021·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Keith M KerrReinhard Büttner
Apr 30, 2021·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·David M HwangMing-Sound Tsao
Aug 1, 2021·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Bregje M KoomenStefan M Willems

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Methods Mentioned

BETA
biopsy
biopsies

Software Mentioned

SNOMED

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