The prevalence of thrombophilia in patients with chronic venous leg ulceration

Journal of Vascular Surgery
R K MacKenzieA W Bradbury

Abstract

Thrombophilia is increasingly recognized as a risk factor for deep venous thrombosis (DVT), which in turn is a major risk factor for chronic venous ulceration (CVU). However, the relationship between thrombophilia and CVU remains unknown. The aim of this study was to define the prevalence of thrombophilia in patients with CVU and to determine whether this is associated with a history or duplex scan evidence of DVT. Eighty-eight patients with CVU were prospectively studied. The patients underwent clinical assessment and duplex ultrasound scanning. Blood was drawn for antithrombin, proteins C and S, activated protein C resistance, factor V Leiden, prothrombin 20210A, lupus anticoagulant, and anticardiolipin antibodies. The study included 35 men with a median age of 61 years (interquartile range, 45 to 72 years) and 53 women with a median age of 76 years (interquartile range, 69 to 82 years). Thirty-six percent of the patients had either a history or duplex scan evidence suggestive of previous DVT. The following abnormalities were detected: four, five, and six cases of antithrombin, protein C, and protein S deficiencies, respectively; 14 cases of activated protein C resistance; 11 cases of factor V Leiden mutation; three cases of ...Continue Reading

References

Jun 22, 1985·British Medical Journal·M J CallamJ J Dale
Feb 14, 1998·The British Journal of Surgery·J BrittendenC V Ruckley
Jan 1, 1997·Dermatology : International Journal for Clinical and Investigative Dermatology·J Hafner, A von Felten
Nov 11, 1998·Journal of Vascular Surgery·W P StuartA W Bradbury
Jan 29, 1999·Archives of Dermatology·M B Maessen-VischH A Neumann
May 20, 1999·Baillière's Clinical Haematology·G F Pineo, R D Hull

❮ Previous
Next ❯

Citations

Aug 20, 2003·Asian Journal of Surgery·Andrew W Bradbury
Jan 1, 2014·Journal of Vascular Surgery. Venous and Lymphatic Disorders·Annemieke C BoumanArina J Ten Cate-Hoek
Jan 1, 2013·Journal of Vascular Surgery. Venous and Lymphatic Disorders·Jaime Benarroch-GampelLois A Killewich
Jan 1, 2009·The Journal of the American College of Certified Wound Specialists·Honesto Poblete, Steven Elias
Sep 30, 2004·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Donato GemmatiPaolo Zamboni
May 10, 2006·British Journal of Haematology·Vikki G NolanMartin H Steinberg
May 3, 2006·International Wound Journal·Kathryn R Vowden, Peter Vowden
Nov 6, 2008·Journal of Thrombosis and Haemostasis : JTH·L W TickC J M Doggen
Jan 5, 2008·International Journal of Dermatology·Hebert Roberto Clivati BrandtPaulo Ricardo Criado
Oct 24, 2008·The British Journal of Dermatology·H R C BrandtP R Criado
Mar 3, 2011·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Markus ZuttLutz Kretschmer
Mar 12, 2011·Journal of the European Academy of Dermatology and Venereology : JEADV·M ZuttL Kretschmer
May 9, 2006·Free Radical Biology & Medicine·Leo R Zacharski, Cocav A Engman
Jun 14, 2013·International Journal of Vascular Medicine·Anat Rabinovich, Susan R Kahn
Mar 25, 2009·Journal of Vascular Surgery·Katy A L DarvallAndrew W Bradbury
Jul 20, 2010·Journal of Vascular Surgery·Peter NeglenCees Wittens
Jan 18, 2008·Journal of Vascular Surgery·Mark H MeissnerSeshadri Raju
Aug 15, 2003·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·R K MacKenzieC V Ruckley
Aug 5, 2008·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·A RosalesA J Kroese
Apr 16, 2013·Journal of the American Academy of Dermatology·Laura A ThornsberryJoseph C English
Jan 17, 2012·Polski przeglad chirurgiczny·Lukasz DzieciuchowiczGaudencio Espinosa
Sep 21, 2012·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Halil Fatih AsgunOzturk Ozdemir
May 28, 2014·The International Journal of Lower Extremity Wounds·Paulo Ricardo CriadoRobert S Kirsner
Jul 31, 2013·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Raghid Kreidy
Jun 2, 2009·Journal of Cutaneous Medicine and Surgery·Zaki A Taher, Alain Brassard
Apr 10, 2004·Home Healthcare Nurse·Deidre D Wipke-Tevis, Wipa Sae-Sia
Aug 28, 2014·Journal of the American Heart Association·Bengt ZöllerKristina Sundquist
Nov 16, 2010·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Adam WiszniewskiKsenia Bykowska
Oct 12, 2005·Advances in Skin & Wound Care·Deidre D Wipke-Tevis, Wipa Sae-Sia
Nov 19, 2011·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Adam WiszniewskiJacek Proniewski
Nov 26, 2009·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Antonio RosalesGunnar Sandbaek
Jul 9, 2011·Anais Brasileiros De Dermatologia·Thelma Larocca Skare
Mar 16, 2004·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Bernard Noël
Jan 14, 2010·Revista do Colégio Brasileiro de Cirurgiões·Thelma Laroka SkareJan Pawel Andrade Pachnicki
Jan 16, 2010·Revista do Colégio Brasileiro de Cirurgiões·Thelma Laroka SkareVinícius Ribas Carvalho Duarte Fonseca
Mar 28, 2020·International Angiology : a Journal of the International Union of Angiology·Andrew NicolaidesMichel Perrin
Jun 11, 2021·Seminars in Interventional Radiology·Sarah E Schroeppel DeBackerJeffrey L Weinstein
Sep 24, 2021·Polski przeglad chirurgiczny·Paweł ZawadzkiLukasz Dzieciuchowicz

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Related Papers

European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery
A W BradburyChristopher D Fegan
Indian Journal of Dermatology, Venereology and Leprology
Ana M CalistruFilomena Azevedo
Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society
Adam WiszniewskiJacek Proniewski
© 2022 Meta ULC. All rights reserved